WAY-100635 Maleate , ≥99% , 1092679-51-0

CAS NO.：1092679-51-0

Empirical Formula: C29H38N4O6

Molecular Weight: 538.65

MDL number:

PRODUCT Properties

• storage temp.: Store at -20°C
• solubility: ≥53.9 mg/mL in DMSO; ≥51.2 mg/mL in EtOH; ≥6.08 mg/mL in H2O with ultrasonic
• form: solid
• color: White to off-white
• Water Solubility: Soluble to 25 mM in water

Description and Uses

WAY-100635 is a potent, silent antagonist of serotonin 5-HT_1A receptors with an IC₅₀ value of 2.2 nM (K_i = 0.8 nM) for inhibiting 5-HT_1A receptors in rat hippocampal membranes. Because it displays 100-fold selectivity for 5-HT_1A over other 5-HT subtypes, WAY-100635 is classically used to examine the distribution and function of 5-HT_1A receptors. However, WAY-100635 has also been shown to exhibit agonist activity at dopamine D₄ receptors (K_d = 2.4 nM).

WAY-100635 maleate is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 maleate has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 maleate is also a potent dopamine D4 receptor agonist[1][2][3].

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• HS Code: 2933.59.8000