5-Azacytidine , 98% , 320-67-2

Synonym(s):
4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one;5′AzaC, 5-Azacitidine, Zcyd, 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one;5-Azacitidine;5-Azacytidine;Ladakamycin

CAS NO.：320-67-2

Empirical Formula: C8H12N4O5

Molecular Weight: 244.2

MDL number: MFCD00006539

EINECS: 206-280-2

PRODUCT Properties

• Melting point: 226-232 °C (dec.)(lit.)
• Boiling point: 387.12°C (rough estimate)
• alpha: 40 º (C=1, H2O 22 ºC)
• Density: 1.4287 (rough estimate)
• refractive index: 1.6590 (estimate)
• storage temp.: -20°C
• solubility: Soluble in DMSO (up to 25 mg/ml), or in Water (up to 12 mg/ml).
• form: lyophilized powder
• pka: 13.46±0.70(Predicted)
• color: White to Off-white
• Water Solubility: 0.5-1.0 g/100 mL at 21 ºC
• Merck: 14,887
• BRN: 620461
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
• InChIKey: NMUSYJAQQFHJEW-WGDKFINWSA-N
• LogP: -2.191 (est)

Description and Uses

5-Azacytidine is an analog of the nucleoside cytidine which can be incorporated into DNA and RNA. 5-Azacytidine acts as an epigenetic modifier by incorporating into DNA where it irreversibly binds to DNA methyltransferases, thus inhibiting their activity.
Azacitidine is an antineoplastic agent launched for the treatment of myelodysplastic syndrome (MDS). MDS is a group of closely related diseases caused by abnormal blood-forming stem cells of the bone marrow. Azacitidine is indicated for the treatment of all five subtypes of MDS, which consist of refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia.

antianginal

Safety

• Symbol(GHS): GHS07,GHS08,GHS09
• Signal word: Danger
• Hazard statements: H302-H341-H350-H360FD-H372-H410
• Precautionary statements: P202-P260-P264-P273-P301+P312-P308+P313
• Hazard Codes: T
• Risk Statements: 45-46-22
• Safety Statements: 53-22-36/37/39-45
• WGK Germany: 3
• RTECS: XZ3017500
• F: 10-23
• HS Code: 29349990
• Toxicity: LD50 in mice (mg/kg): 115.9 i.p.; 572.3 orally (Palm, Kensler)