A7034658
Amoxapine , 2mMinDMSO , 14028-44-5
Synonym(s):
2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine;Amoxapine
CAS NO.：14028-44-5
Empirical Formula: C17H16ClN3O
Molecular Weight: 313.78
MDL number: MFCD00069210
EINECS: 237-867-1
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 175-1760C |
| Boiling point: | 469.9±55.0 °C(Predicted) |
| Density | 1.2613 (rough estimate) |
| refractive index | 1.5800 (estimate) |
| Flash point: | 9℃ |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | methanol: soluble |
| form | Solid |
| pka | pKa 7.6 (Uncertain) |
| color | Crystals from benzene/pet ether |
| Merck | 14,576 |
| Stability: | Stable under recommended storage conditions., Stable Under Recommended Storage C |
Description and Uses
Amoxapine is a tetracyclic antidepressant with a wide range of pharmacological effects. It inhibits norepinephrine and serotonin reuptake, binding the respective transporters with Kd values of 16 and 58 nM. It has also been shown to act as either an antagonist or inverse agonist at serotonin 5-HT2A, 2B, 2C, 3, 6, 7 (Kis = 1 and 2 nM for 5-HT2A and 5-HT2C, respectively), dopamine D2, 3, 4 (Kd = 160 nM for D2), α1-adrenergic (Kd = 50 nM), and histamine H1 (Kd = 25 nM) receptors.
A tricyclic norepinephrine uptake inhibitor
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 36 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | HQ4025500 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 2934990002 |
| Toxicity | LD50 in mice (mg/kg): 122 i.p.; 112 orally (Howell, 1972) |
