Amoxapine , ≥98% , 14028-44-5

Synonym(s):
2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine;Amoxapine

CAS NO.：14028-44-5

Empirical Formula: C17H16ClN3O

Molecular Weight: 313.78

MDL number: MFCD00069210

EINECS: 237-867-1

PRODUCT Properties

• Melting point: 175-1760C
• Boiling point: 469.9±55.0 °C(Predicted)
• Density: 1.2613 (rough estimate)
• refractive index: 1.5800 (estimate)
• Flash point: 9℃
• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• solubility: methanol: soluble
• form: Solid
• pka: pKa 7.6 (Uncertain)
• color: Crystals from benzene/pet ether
• Merck: 14,576
• Stability: Stable under recommended storage conditions., Stable Under Recommended Storage C
• CAS DataBase Reference: 14028-44-5(CAS DataBase Reference)
• NIST Chemistry Reference: Amoxapine(14028-44-5)

Description and Uses

Amoxapine is a tetracyclic antidepressant with a wide range of pharmacological effects. It inhibits norepinephrine and serotonin reuptake, binding the respective transporters with K_d values of 16 and 58 nM. It has also been shown to act as either an antagonist or inverse agonist at serotonin 5-HT_2A, _2B, _2C, ₃, ₆, ₇ (K_is = 1 and 2 nM for 5-HT_2A and 5-HT_2C, respectively), dopamine D₂, ₃, ₄ (K_d = 160 nM for D₂), α₁-adrenergic (K_d = 50 nM), and histamine H₁ (K_d = 25 nM) receptors.

A tricyclic norepinephrine uptake inhibitor

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P501
• Hazard Codes: Xn
• Risk Statements: 22
• Safety Statements: 36
• RIDADR: 3249
• WGK Germany: 3
• RTECS: HQ4025500
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 2934990002
• Toxicity: LD50 in mice (mg/kg): 122 i.p.; 112 orally (Howell, 1972)