cis-Capsaicin , 10mMinDMSO , 25775-90-0
CAS NO.：25775-90-0
Empirical Formula: C18H27NO3
Molecular Weight: 305.41
MDL number: MFCD00209942
EINECS: 636-760-0
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 70 °C |
| Boiling point: | 511.5±50.0 °C(Predicted) |
| Density | 1.041±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.76±0.20(Predicted) |
| color | White to Off-White |
| Stability: | Light Sensitive |
Description and Uses
Zucapsaicin is a topical analgesic that was approved in Canada in July 2010 for use in conjunction with oral COX-2 inhibitors or NSAIDs to relieve severe pain in adults with osteoarthritis of the knee. Zucapsaicin is the cis-isomer of the natural product capsaicin. Capsaicin is available without a prescription in creams, lotions, and patches for the treatment of neuropathic and musculoskeletal pain. Zucapsaicin is available as a 0.075% by weight cream. The advantages of zucapsaicin compared with capsaicin are reported to be a lesser degree of local irritation (stinging, burning, erythema) in patients and a greater degree of efficacy in preclinical animal models of pain. The analgesic action of zucapsaicin and capsaicin is mediated through the transient receptor potential vanilloid type 1 (TRPV1) channel.
(Z)-CAPSAICIN is used as a tool in neurobiological research. Prototype vanilloid receptor agonist.
Safety
| Symbol(GHS) |    GHS08,GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H301-H335-H334-H317-H318-H315 |
| Precautionary statements | P280-P305+P351+P338-P310-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P285-P304+P341-P342+P311-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P310-P321-P330-P405-P501 |
| Toxicity | LD50 intraperitoneal in mouse: 25mg/kg |
