Home Categories Chemical Reagents Carbonylcyanide4-(trifluoromethoxy)phenylhydrazone
A6949858

Carbonylcyanide4-(trifluoromethoxy)phenylhydrazone , 10mMinDMSO , 370-86-5

Synonym(s):
FCCP;Mesoxalonitrile 4-trifluoromethoxyphenylhydrazone

CAS NO.:370-86-5

Empirical Formula: C10H5F3N4O

Molecular Weight: 254.17

MDL number: MFCD00009699

EINECS: 206-730-8

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 174-175 °C (dec.)(lit.)
Boiling point: 293.3±50.0 °C(Predicted)
Density  1.34±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  acetone: 20 mg/mL, clear, very deep greenish yellow
form  powder
pka 5.91±0.10(Predicted)
color  yellow
BRN  664446
Stability: Stable for 2 years from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
CAS DataBase Reference 370-86-5

Description and Uses

FCCP (370-86-5) is an extremely potent uncoupler of mitochondrial oxidative phosphorylation (IC50 = 20 nM).1 Induces apoptosis in a variety of cell lines.2 Inhibits wild type and mutant beta-amyloid production in embryonic kidney 293 cells expressing either wild-type or “Swedish” mutant APP.3 An important tool for inhibiting mitochondrial membrane potential.2,4 Cell permeable.

FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes. At 40 μM, FCCP induces complete depolymerization of microtubules by increasing intracellular pH via the disruption of the mitochondrial H+ gradient and by decreasing the stability of microtubules by impairing the binding of microtubule-associated proteins.[Cayman Chemical]

Safety

Symbol(GHS) 
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H314-H317-H413
Precautionary statements  P260-P273-P280-P301+P312-P303+P361+P353-P305+P351+P338
Hazard Codes  T,Xi
Risk Statements  25-43
Safety Statements  36/37-45
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  FG5775000
Hazard Note  Irritant
HazardClass  6.1(a)
PackingGroup  II
HS Code  2928009090

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