Carbonylcyanide4-(trifluoromethoxy)phenylhydrazone , 10mMinDMSO , 370-86-5

Synonym(s):
FCCP;Mesoxalonitrile 4-trifluoromethoxyphenylhydrazone

CAS NO.：370-86-5

Empirical Formula: C10H5F3N4O

Molecular Weight: 254.17

MDL number: MFCD00009699

EINECS: 206-730-8

PRODUCT Properties

• Melting point: 174-175 °C (dec.)(lit.)
• Boiling point: 293.3±50.0 °C(Predicted)
• Density: 1.34±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: acetone: 20 mg/mL, clear, very deep greenish yellow
• form: powder
• pka: 5.91±0.10(Predicted)
• color: yellow
• BRN: 664446
• Stability: Stable for 2 years from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

Description and Uses

FCCP (370-86-5) is an extremely potent uncoupler of mitochondrial oxidative phosphorylation (IC50 = 20 nM).1 Induces apoptosis in a variety of cell lines.2 Inhibits wild type and mutant beta-amyloid production in embryonic kidney 293 cells expressing either wild-type or “Swedish” mutant APP.3 An important tool for inhibiting mitochondrial membrane potential.2,4 Cell permeable.

FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes. At 40 μM, FCCP induces complete depolymerization of microtubules by increasing intracellular pH via the disruption of the mitochondrial H+ gradient and by decreasing the stability of microtubules by impairing the binding of microtubule-associated proteins.[Cayman Chemical]

Safety

• Symbol(GHS): GHS05,GHS07
• Signal word: Danger
• Hazard statements: H302-H314-H317-H413
• Precautionary statements: P260-P273-P280-P301+P312-P303+P361+P353-P305+P351+P338
• Hazard Codes: T,Xi
• Risk Statements: 25-43
• Safety Statements: 36/37-45
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• RTECS: FG5775000
• Hazard Note: Irritant
• HazardClass: 6.1(a)
• PackingGroup: II
• HS Code: 2928009090