Home Categories Chemical Reagents Carbonylcyanide3-chlorophenylhydrazone
A6954758

Carbonylcyanide3-chlorophenylhydrazone , 10mMinDMSO , 555-60-2

Synonym(s):
m-Cl-CCP;Carbonyl Cyanide m-Chlorophenylhydrazone - CAS 555-60-2 - Calbiochem;CCCP;Mesoxalonitrile 3-chlorophenylhydrazone

CAS NO.:555-60-2

Empirical Formula: C9H5ClN4

Molecular Weight: 204.62

MDL number: MFCD00001848

EINECS: 209-103-7

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 170-175 °C (dec.)
Boiling point: 333.84°C (rough estimate)
Density  1.3807 (rough estimate)
refractive index  1.6110 (estimate)
storage temp.  -20°C
solubility  methanol: 10 mg/mL, clear, very deep yellow
form  powder
pka 6.00±0.10(Predicted)
color  yellow to orange
Water Solubility  Insoluble in water. Soluble in DMSO (5 mg/ml), ethanol (1 mg/ml) and methanol (10 mg/ml).
BRN  1842102
Exposure limits NIOSH: IDLH 25 mg/m3
InChIKey UGTJLJZQQFGTJD-UHFFFAOYSA-N
CAS DataBase Reference 555-60-2(CAS DataBase Reference)
EPA Substance Registry System Propanedinitrile, [(3-chlorophenyl)hydrazono]- (555-60-2)

Description and Uses

CCCP is a protonophore mitochondrial uncoupler that increases membrane permeability to protons, leading to a disruption in the mitochondrial membrane potential. It inhibits mitochondrial respiration and ATPase activity when used at concentrations of 110 and 35 nM, respectively. CCCP inhibits activation of stimulation of interferon genes (STING), decreasing the expression of downstream STING targets, including IFN-β, TBK1, and IRF3 when used at a concentration of 50 μM in RAW 264.7 cells. It induces mitochondrial fission in a manner dependent on the GTPase Drp1. CCCP (4 mg/kg) increases body temperature as well as left ventricular systolic and diastolic dimensions and decreases fractional shortening in rats. It also increases myocardial glucose and fatty acid uptake in rats.

Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) has been used:

  • in the inhibition of efflux pump in clinical Pseudomonas aeruginosa
  • to inhibit oxidative phosphorylation activity of mitochondria in human Beas-2B bronchial epithelial cells
  • to prepare carbonyl cyanide m-chlorophenylhydrazone solution for oxidative and mitochondrial stress assay and mitophagy induction in Caenorhabditis elegans

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301+H311+H331-H315-H319-H335
Precautionary statements  P261-P280-P301+P310-P302+P352+P312-P304+P340+P311-P305+P351+P338
Hazard Codes  T
Risk Statements  23/24/25-36/37/38
Safety Statements  26-36/37-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  FG5600000
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29280090

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