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A2369512

Citrinin , 98% , 518-75-2

Synonym(s):
CIT;Citron protein;CTRO;Rho-interacting;(3R,4S)-8-Hydroxy-3,4,5-Trimethyl-6-Oxo-4,6-Dihydro-3H-Isochromene-7-Carboxylic Acid

CAS NO.:518-75-2

Empirical Formula: C13H14O5

Molecular Weight: 250.25

MDL number: MFCD00006912

EINECS: 208-257-2

Pack Size Price Stock Quantity
5MG RMB1598.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 175°C (dec.)
alpha  D18 -37.4° (c = 1.15 in alc.)
Boiling point: 313.38°C (rough estimate)
Density  1.37
refractive index  1.4560 (estimate)
Flash point: 2℃
storage temp.  2-8°C
solubility  ≤2mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
form  Crystalline Powder or Flakes
pka 1.52±0.60(Predicted)
color  Yellow
Merck  13,2351
BRN  5282243
Stability: Hygroscopic
CAS DataBase Reference 518-75-2(CAS DataBase Reference)
IARC 3 (Vol. 40, Sup 7) 1987
EPA Substance Registry System Citrinin (518-75-2)

Description and Uses

Citrinin is a mycotoxin that has been found in Monascus and has diverse biological activities. It is active against S. aureus, methicillin-resistant S. aureus (MRSA), rifampicin-resistant S. aureus, and vancomycin-resistant E. faecium (MICs = 1.95, 3.9, 0.97, and 7.81 μg/ml, respectively), as well as the pathogenic yeast C. neoformans (MIC = 3.9 μg/ml). It is cytotoxic to a variety of cells in vitro, including bovine kidney cells and mice embryonic stem cells. Citrinin (30 μM) induces reactive oxygen species (ROS) production, mitochondrial membrane potential loss, and apoptosis in HepG2 cells, effects that can be blocked by the antioxidant resveratrol. In contrast, citrinin reduces glutamate-induced excitotoxicity in primary rat cortical neurons at concentrations ranging from 0.1 to 1,000 nM and inhibits LPS-induced production of nitric oxide (NO) in RAW 264.7 cells at 0.625 to 40 μM. It is toxic to brine shrimp larvae (LD50 = 96 μg/ml), as well as to rats and mice with oral LD50 values of 50 and 87-105 mg/kg, respectively. It induces reproductive abnormalities in male mice and toxic effects in the liver, kidney, heart, and gastrointestinal tracts of various animals. Citrinin has been found in stored cereal grains, as well as beans, fruit, and herbs.

antibacterial

Safety

Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H301+H311+H331-H351
Precautionary statements  P202-P261-P280-P301+P310-P302+P352+P312-P304+P340+P311
Hazard Codes  T
Risk Statements  23/24/25-40-36/37/38
Safety Statements  26-36/37/39-45-22-7/9
RIDADR  UN 3462 6.1/PG 3
WGK Germany  3
RTECS  DJ2275000
HazardClass  6.1(a)
PackingGroup  II
HS Code  29419090
Hazardous Substances Data 518-75-2(Hazardous Substances Data)
Toxicity LD50 in mice, rats (mg/kg): 35, 67 i.p. (Ambrose, De Eds)

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