Norethindrone , ≥98% , 68-22-4

Synonym(s):
Norethindrone;19-Norethindrone;ELK;EPB1;Eph receptor B1

CAS NO.：68-22-4

Empirical Formula: C20H26O2

Molecular Weight: 298.43

MDL number: MFCD00067596

EINECS: 200-681-6

PRODUCT Properties

• Melting point: 205-206 °C (lit.)
• Boiling point: 379.83°C (rough estimate)
• alpha: D20 -31.7° (chloroform); D20 -25° (chloroform)
• Density: 1.0766 (rough estimate)
• refractive index: 1.4800 (estimate)
• storage temp.: 2-8°C
• solubility: chloroform: ≥50 mg/mL, clear, colorless
• form: powder
• pka: 13.09±0.40(Predicted)
• color: white to off-white
• Water Solubility: 7.043mg/L(25 ºC)
• Merck: 6697
• BRN: 1915671
• BCS Class: 1
• InChIKey: VIKNJXKGJWUCNN-XGXHKTLJSA-N

Description and Uses

Norethindrone is a progestin (a synthetic substance with properties similar to progesterone) that is best known as the first female oral contraceptive, or the “pill.”Norethindrone’s global impact on society and culture has made it one of the most important inventions in history.

Progestin contraceptives work by producing pregnant-like conditions in a female to preventovulation.During pregnancy, progesterone is released by the placenta during development ofthe fetus.This in turn suppresses development of egg follicles and ovulation. Progestins mimicthis condition and thus prevent or delay ovulation.Oral contraceptives currently use progestinand estrogen in combination to prevent ovulation and thicken cervical mucus.The latter makeit harder for sperm to enter the uterus and for an egg to implant on the uterine wall.

Safety

• Symbol(GHS): GHS08,GHS09
• Signal word: Danger
• Hazard statements: H351-H360FD-H362-H410
• Precautionary statements: P202-P260-P263-P264-P273-P308+P313
• Hazard Codes: Xn
• Risk Statements: 40-36/37/38-20/21/22
• Safety Statements: 22-36/37/39-45-37/39-26
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• RTECS: RC8975000
• HS Code: 29144000
• Toxicity: LD50 oral in mouse: 6gm/kg