A6205112
Necrostatin-1 , ≥99% , 4311-88-0
Synonym(s):
5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone;5-(Indol-3-ylmethyl)-3-methyl-2-thio-Hydantoin;MTH-DL-Tryptophan;Necrostatin-1 - CAS 4311-88-0 - Calbiochem
CAS NO.：4311-88-0
Empirical Formula: C13H13N3OS
Molecular Weight: 259.33
MDL number: MFCD00056916
EINECS: 200-256-5
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB319.20 | In Stock |
|
| 50MG | RMB639.20 | In Stock |
|
| 100mg | RMB975.20 | In Stock |
|
| 250mg | RMB1462.40 | In Stock |
|
| 1g | RMB3647.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 151℃ |
| Boiling point: | 441.9±37.0 °C(Predicted) |
| Density | 1.40±0.1 g/cm3 (20 ºC 760 Torr) |
| Flash point: | 93.3℃ |
| storage temp. | -20°C |
| solubility | DMSO: >10 mg/mL |
| form | solid |
| pka | 9.46±0.40(Predicted) |
| color | Pale yellow |
| Sensitive | Light Sensitive |
| Stability: | Stable for 2 years from date of purchase as supplied.? Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
Description and Uses
Necrostatin-1 (4311-88-0) is an inhibitor of necroptosis (non-apoptotic cell death pathway; EC50 = 494 nM).1 It is an ATP-competitive death domain receptor-associated adaptor kinase (RIP1) inhibitor (EC50 = 182 nM).2 Necrostatin-1 displays a protective effect in a mouse model of ischemic brain injury1, inhibits myocardial cell death and reduces infarct size in various mouse heart models3 and inhibits glutamate-induced oxytosis in HT-22 cells4.
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.
