Z-VAD(OMe)-FMK , 98% , 187389-52-2

Synonym(s):
caspase 3;caspase 3, apoptosis-related cysteine peptidase;caspase 3, apoptosis-related cysteine protease;N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone;Z-VAD (OMe)-FMK

CAS NO.：187389-52-2

Empirical Formula: C22H30FN3O7

Molecular Weight: 467.49

MDL number: MFCD03452883

PRODUCT Properties

• Melting point: >190°C (dec.)
• Boiling point: 732.4±60.0 °C(Predicted)
• Density: 1.214±0.06 g/cm3 (20 ºC 760 Torr)
• Flash point: 396.7℃
• storage temp.: -20°C
• solubility: DMSO: 20 mg/mL
• form: powder
• pka: 11.05±0.46(Predicted)
• color: white
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
• InChIKey: MIFGOLAMNLSLGH-QOKNQOGYSA-N
• SMILES: C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)[C@@H](CC(OC)=O)C(=O)CF
• CAS DataBase Reference: 187389-52-2

Description and Uses

Z-VAD-FMK (187389-52-2), cell-permeable, methyl ester form. Potent, irreversible pan-caspase inhibitor. Inhibits caspase activity and apoptosis induction in a variety of cell types (IC50 = 1.5 μM). Active in vivo.

Z-VAD(OMe)-FMK is a cell-permeable, competitive, and irreversible inhibitor of all caspases. Through this action, it inhibits cleavage of poly(ADP-ribose) polymerase, preventing apoptosis when used at 10-50 μM. It also blocks caspase-mediated apoptosis in vivo. Z-VAD(OMe)-FMK effectively prevents caspase action in inflammasomes.[Cayman Chemical]

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
• Safety Statements: 22-24/25
• WGK Germany: 3
• HS Code: 29145090