Ionomycin (free acid) , ≥98%(HPLC) , 56092-81-0
Synonym(s):
Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem;Ionomycin, Free Acid, Streptomyces conglobatus in Solution - CAS 56092-81-0 - Calbiochem;SQ23377 calcium
| Pack Size | Price | Stock | Quantity |
| 1MG | RMB455.20 | In Stock |
|
| 5MG | RMB1599.20 | In Stock |
|
| 25MG | RMB5599.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 817.2±65.0 °C(Predicted) |
| Density | 1.072±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | Soluble to 10 mM in Ethanol and to 10 mM in DMSO. |
| form | Waxy solid |
| pka | 4.77±0.10(Predicted) |
| color | Yellow |
| BRN | 3642126 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
Description and Uses
Ionomycin (56092-81-0) is a highly selective nonfluorescent calcium (Ca2+) ionophore.1 Induces a rapid rise in cytosolic Ca2+ in human neutrophils which is due to both release from cytosolic Ca2+ stores as well as Ca2+ influx.2 It activates (2 μM) and primes (20-200 nM) neutrophil NADPH oxidase2. Down regulates beta-catenin/Tcf signaling in a colon cancer cell line via suppressing the binding of Tcf to its specific DNA-binding site.3 In rat hepatoma cells, sub-lethal ionomycin activates the stress response by activating SAPK/JNK and HSF/HSE interaction leading to upregulation of HSP70 biosynthesis.4
Ionomycin was isolated from Streptomyces conglobatus as a potent Gram positive antibiotic . During isolation, it was recognised that ionomycin exhibits a very high affinity and selectivity for calcium ions, suggesting the metabolite acts as a calcium ionophore. More recently, ionomycin has been used in cell biology as a universal calcium ionophore to explore the role of calcium regulation in the cell.
Safety
| Symbol(GHS) |  GHS02 |
| Signal word | Warning |
| Hazard statements | H225 |
| Precautionary statements | P210-P240-P241-P280a-P303+P361+P353-P501a |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 36-36/37/39-27-26-24/25 |
| WGK Germany | 3 |
| RTECS | NO0650000 |
| F | 8-10 |
| HazardClass | 3 |
| HS Code | 29419090 |
