A1170650
ActinomycinD , 98% , 50-76-0
Synonym(s):
Dactinomycin;Actinomycin D;Actinomycin D solution from Streptomyces sp.;Actinomycin D, Streptomyces sp. - CAS 50-76-0 - Calbiochem;Actinomycin IV
CAS NO.：50-76-0
Empirical Formula: C62H86N12O16
Molecular Weight: 1255.42
MDL number: MFCD00005033
EINECS: 200-063-6
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 251-253 °C |
| Boiling point: | 848°C (rough estimate) |
| Density | 1.0757 (rough estimate) |
| refractive index | 1.5700 (estimate) |
| Flash point: | 87℃ |
| storage temp. | 2-8°C |
| solubility | ethanol, DMSO: Stable in aqueous solutions at 2-8 °C.soluble |
| form | powder |
| pka | 8.94±0.70(Predicted) |
| color | red, powder |
| optical activity | [α]/D alpha: 28/D (Rotation: -315 degrees (c=0.25% in methanol)) |
| Water Solubility | SOLUBLE |
| Merck | 13,2828 |
| BRN | 605235 |
| Stability: | Stable, but light sensitive, especially in dilute solution. Incompatible with strong acids, strong bases, strong oxidizing agents. Combustible. |
| CAS DataBase Reference | 50-76-0(CAS DataBase Reference) |
| IARC | 3 (Vol. 10, Sup 7) 1987 |
| EPA Substance Registry System | Actinomycin D (50-76-0) |
Description and Uses
Actinomycin D (50-76-0) is a cyclopeptide antibiotic and intercalating transcription inhibitor with anti-neoplastic activity. Potent inhibitor of RNA polymerase.1?Induces apoptosis in a variety of cancer cell lines2,3via the intrinsic pathway4.? Upregulates proapoptotic PUMA and downregulates Bcl-2 mRNA in peripheral blood lymphocytes.5
An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent.
Safety
| Symbol(GHS) |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H300-H350-H360FD |
| Precautionary statements | P201-P202-P264-P270-P280-P301+P310 |
| Hazard Codes | T+ |
| Risk Statements | 28-61-40-45-26/27/28 |
| Safety Statements | 53-36/37/39-45-1-36/37-28-22 |
| RIDADR | UN 3462 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | AU1575000 |
| F | 8-10-21 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| HS Code | 29419000 |
| Hazardous Substances Data | 50-76-0(Hazardous Substances Data) |
| Toxicity | LD50 oral in rat: 7200ug/kg |
