ActinomycinD , 98% , 50-76-0

Synonym(s):
Dactinomycin;Actinomycin D;Actinomycin D solution from Streptomyces sp.;Actinomycin D, Streptomyces sp. - CAS 50-76-0 - Calbiochem;Actinomycin IV

CAS NO.：50-76-0

Empirical Formula: C62H86N12O16

Molecular Weight: 1255.42

MDL number: MFCD00005033

EINECS: 200-063-6

PRODUCT Properties

• Melting point: 251-253 °C
• Boiling point: 848°C (rough estimate)
• Density: 1.0757 (rough estimate)
• refractive index: 1.5700 (estimate)
• Flash point: 87℃
• storage temp.: 2-8°C
• solubility: ethanol, DMSO: Stable in aqueous solutions at 2-8 °C.soluble
• form: powder
• pka: 8.94±0.70(Predicted)
• color: red, powder
• optical activity: [α]/D alpha: 28/D (Rotation: -315 degrees (c=0.25% in methanol))
• Water Solubility: SOLUBLE
• Merck: 13,2828
• BRN: 605235
• Stability: Stable, but light sensitive, especially in dilute solution. Incompatible with strong acids, strong bases, strong oxidizing agents. Combustible.

Description and Uses

Actinomycin D (50-76-0) is a cyclopeptide antibiotic and intercalating transcription inhibitor with anti-neoplastic activity. Potent inhibitor of RNA polymerase.1?Induces apoptosis in a variety of cancer cell lines2,3via the intrinsic pathway4.? Upregulates proapoptotic PUMA and downregulates Bcl-2 mRNA in peripheral blood lymphocytes.5

An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent.

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H300-H350-H360FD
• Precautionary statements: P201-P202-P264-P270-P280-P301+P310
• Hazard Codes: T+
• Risk Statements: 28-61-40-45-26/27/28
• Safety Statements: 53-36/37/39-45-1-36/37-28-22
• RIDADR: UN 3462 6.1/PG 2
• WGK Germany: 3
• RTECS: AU1575000
• F: 8-10-21
• HazardClass: 6.1(a)
• PackingGroup: II
• HS Code: 29419000
• Toxicity: LD50 oral in rat: 7200ug/kg