A1141550
Cycloheximide , 95% , 66-81-9
Synonym(s):
CHX;Actidione;Cycloheximide - CAS 66-81-9 - Calbiochem;Cycloheximide, High Purity - CAS 66-81-9 - Calbiochem;InSolution Cycloheximide - CAS 66-81-9 - Calbiochem
CAS NO.：66-81-9
Empirical Formula: C15H23NO4
Molecular Weight: 281.35
MDL number: MFCD06202064
EINECS: 200-636-0
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 111-116 °C |
| alpha | -28.5 º (c=1, CHCl3) |
| Boiling point: | 492℃ |
| Density | 1.0867 (rough estimate) |
| refractive index | 1.5000 (estimate) |
| Flash point: | 87°0°(230°F) |
| storage temp. | 2-8°C |
| solubility | Soluble in Ethanol (up to 14 mg/ml) or in Water (up to 7 mg/ml). |
| form | Glassy Irregular Shaped Granules |
| pka | 11.61±0.40(Predicted) |
| color | White |
| biological source | microbial |
| Water Solubility | 2.1 g/100 mL (2 ºC) |
| BRN | 88868 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, alkali. |
| CAS DataBase Reference | 66-81-9(CAS DataBase Reference) |
| EPA Substance Registry System | Cycloheximide (66-81-9) |
Description and Uses
Cycloheximide is a glutarimide-type antibiotic produced by Streptomyces griseus. Colorless crystals, C15H23NO4 (281.4), melting point: 115.5–117 ?C, weak acidic substance (pKa 11.2), Soluble in chloroform, isopropanol and methanol; water > 21 g/L (2 ?C). Stable in pH 3–5, but rapidly destroyed in alkaline solutions.
Cycloheximide is an antibiotic substance isolated from the beers of streptomycin-producing strains of Streptomyces griseus. Cycloheximide is used as fungicide.
Safety
| Symbol(GHS) |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H301-H341-H360D-H412 |
| Precautionary statements | P201-P202-P264-P270-P273-P301+P310 |
| Hazard Codes | Xn,T,N,T+ |
| Risk Statements | 22-68-61-51/53-28-38-52/53 |
| Safety Statements | 53-45-61-36/37-28 |
| RIDADR | UN 2811 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | MA4375000 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| HS Code | 29419000 |
| Hazardous Substances Data | 66-81-9(Hazardous Substances Data) |
| Toxicity | LD50 i.v. in mice: 150 mg/kg (Leach) |
| Limited Quantities | 100ml (liquid) or 0.5 Kg (solid) |
| Excepted Quantities | Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml) |
