A4644812
GSK3787 , ≥98% , 188591-46-0
Synonym(s):
4-Chloro-N-(2-((5-trifluoromethyl)-2-pyridyl)sulfonyl)ethyl)benzamide, PPARβ Antagonist I, PPARδ Antagonist I;4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide;PPARβ/δ Antagonist, GSK3787 - CAS 188591-46-0 - Calbiochem
CAS NO.：188591-46-0
Empirical Formula: C15H12ClF3N2O3S
Molecular Weight: 392.78
MDL number: MFCD00099612
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB519.20 | In Stock |
|
| 50MG | RMB2079.20 | In Stock |
|
| 250MG | RMB6399.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 585.1±50.0 °C(Predicted) |
| Density | 1.448±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥10mg/mL |
| pka | 12.92±0.46(Predicted) |
| form | White solid |
| color | white to off-white |
| Stability: | Stable for 1 year for up to year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 188591-46-0 |
Description and Uses
GSK-3787 (188591-46-0) is a selective and irreversible antagonist of the peroxisome proliferator-activated receptor δ (PPARδ) – plC50 = 6.6. It covalently binds to Cys 249 in the PPARd binding site.
GSK3787 has been used to inhibit the role of peroxisome proliferator-activated receptor-delta (PPARδ), during the pre-implantation period of bovine embryonic development. It has also been used as a PPARδ-specific inhibitor in in vitro maturation (IVM) media to inhibit PPARδ.
