GW9662 , ≥98% , 22978-25-2

CAS NO.：22978-25-2

Empirical Formula: C13H9ClN2O3

Molecular Weight: 276.68

MDL number: MFCD01215270

EINECS: 636-590-7

PRODUCT Properties

• Melting point: 158-159 °C (lit.)
• Boiling point: 360.9±32.0 °C(Predicted)
• Density: 1.440±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: 26 mg/mL, soluble
• form: solid
• pka: 11.77±0.70(Predicted)
• color: white
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
• InChIKey: DNTSIBUQMRRYIU-UHFFFAOYSA-N
• CAS DataBase Reference: 22978-25-2(CAS DataBase Reference)

Description and Uses

GW-9662 (22978-25-2) is a selective PPARγ antagonist (IC50 = 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively).1 Blocks the inhibition of osteoclast formation induced by IL-4 (1-2 μM).2 Displays anticancer activity inhibits growth of human mammary tumor cell lines.3 GW-9662 is a useful tool for dissecting the involvement of PPARγ in cellular physiology.4,5

A cell-permeable, selective and irreversible PPAR antagonist (IC50 = 3.3 nM, 32 nM, and 2 for PPAR, PPARa, and PPARd, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 , also

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H317-H319-H315-H335
• Precautionary statements: P261-P302+P352-P321-P405-P501-P280-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36-43
• Safety Statements: 26-36/37-24/25-22
• WGK Germany: 3
• HS Code: 29242990