Home Categories Biochemical Engineering WY-14643 (Pirinixic Acid)
A8398612

WY-14643 (Pirinixic Acid) , ≥98% , 50892-23-4

Synonym(s):
4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid;Pirinixic acid

CAS NO.:50892-23-4

Empirical Formula: C14H14ClN3O2S

Molecular Weight: 323.8

MDL number: MFCD00191335

Pack Size Price Stock Quantity
250MG RMB454.40 In Stock
1G RMB1100.00 In Stock
5G RMB3724.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 155°C
Boiling point: 514.4±50.0 °C(Predicted)
Density  1.2984 (rough estimate)
refractive index  1.5630 (estimate)
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  Soluble in DMSO (up to 40 mg/ml).
form  White crystalline solid
pka 2.99±0.10(Predicted)
color  Off-white
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months.

Description and Uses

WY-14643 (50892-23-4) is a selective PPARα agonist (EC50=0.63, 32 and >100 μM for PPARα,γ and δ, respectively).1? Displays anti-inflammatory activity2 and reduces LPS-induced inflammation in alveolar epithelial cells3. Induces “browning” of white adipocytes in combined treatment with retinoic acid.4? Stimulates ADAM10-mediated proteolysis of? amyloid precursor protein in a mouse model.5 Down regulates NFkB transcriptional activity. Review.6

A highly potent PPARα agonist

Safety

Symbol(GHS) 
GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H315-H319-H335-H350
Precautionary statements  P201-P301+P312+P330-P302+P352-P305+P351+P338-P308+P313
Hazard Codes  T
Risk Statements  45-22-36/37/38
Safety Statements  53-26-36/37/39-45
WGK Germany  3
RTECS  AG2915000
HS Code  2933.59.9500
Hazardous Substances Data 50892-23-4(Hazardous Substances Data)

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