Home Categories Biochemical Engineering BGJ398 (NVP-BGJ398)
A6206912

BGJ398 (NVP-BGJ398) , ≥98% , 872511-34-7

CAS NO.:872511-34-7

Empirical Formula: C26H31Cl2N7O3

Molecular Weight: 560.48

MDL number: MFCD22123241

Pack Size Price Stock Quantity
5MG RMB341.60 In Stock
25MG RMB631.20 In Stock
100MG RMB1599.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: >211°C (dec.)
Boiling point: 747.9±60.0 °C(Predicted)
Density  1.354
storage temp.  -20°C
solubility  Soluble in DMSO (up to 5 mg/ml)
form  White solid.
pka 11.02±0.70(Predicted)
color  White
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Description and Uses

NVP-BGJ398 (872511-34-7) is a potent and selective pan-FGFR inhibitor (IC50?= 0.9nM, 1.4 nM, 1.0 nM, and 60 nM for FGFR1,2,3,4 respectively).1? It has also been used in a mouse model of Achondroplasia (most common form of dwarfism) to correct pathological hallmarks of this condition.

BGJ 398 is a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.

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