Ethinyl Estradiol , ≥98% , 57-63-6

Synonym(s):
17α-Ethynyl-1,3,5(10)-estratriene-3,17β-diol;17α-Ethynylestradiol;19-Nor-1,3,5(10),17α-pregnatrien-20-yne-3,17-diol;EE;Ethinylestradiol

CAS NO.：57-63-6

Empirical Formula: C20H24O2

Molecular Weight: 296.41

MDL number: MFCD00003690

EINECS: 200-342-2

PRODUCT Properties

• Melting point: 182-183 °C(lit.)
• Boiling point: 378°C (rough estimate)
• Density: 1.0944 (rough estimate)
• refractive index: -30 ° (C=0.4, Pyridine)
• Flash point: 9℃
• storage temp.: room temp
• solubility: ethanol: 50 mg/mL, clear, slightly yellow
• pka: pKa 10.32 (Uncertain)
• form: Solid
• color: White to Light yellow to Light orange
• Merck: 14,3734
• BRN: 2419975
• BCS Class: 3/1
• InChIKey: BFPYWIDHMRZLRN-SLHNCBLASA-N

Description and Uses

Estrogens direct the development of the female genotype in embryogenesis and at puberty. Estradiol is the major estrogen secreted by the premenopausal ovary. Ethynyl estradiol is a synthetic analog of 17β-estradiol . A USP-approved grade of ethynyl estradiol is often formulated in combination with a progestin such as norgestrel /levonorgestrel or desogestrel and provided for use as an oral contraceptive. Efficacy of oral administration of ethynyl estradiol is facilitated by the ethynyl substitution at the C-17 position, which inhibits first pass hepatic metabolism. Ethynyl estradiol is also rapidly and almost completely absorbed from the gastrointestinal tract.

estrogen, plus progestogen as oral contraceptive

Safety

• Symbol(GHS): GHS07,GHS08,GHS09
• Signal word: Danger
• Hazard statements: H302-H350-H410
• Precautionary statements: P202-P264-P270-P273-P301+P312-P308+P313
• Hazard Codes: T,F
• Risk Statements: 45-22-39/23/24/25-23/24/25-11
• Safety Statements: 53-36/37/39-45-36/37-16
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 3
• RTECS: RC8925000
• F: 8
• HS Code: 29372390
• Toxicity: LD50 oral in rat: 960mg/kg