Quinestrol , 152-43-2

Synonym(s):
17α-Ethynyl-1,3,5(10)-estratriene-3,17β-diol 3-cyclopentyl ether;Quinestrol

CAS NO.：152-43-2

Empirical Formula: C25H32O2

Molecular Weight: 364.52

MDL number: MFCD00079189

EINECS: 205-803-1

PRODUCT Properties

• Melting point: 107-108°
• alpha: D25 +5° (c = 0.5 in dioxane)
• Boiling point: 435.69°C (rough estimate)
• Density: 1.0693 (rough estimate)
• refractive index: 1.4480 (estimate)
• storage temp.: 2-8°C
• solubility: Chloroform (Slightly), Dioxane (Slightly), DMSO (Slightly), Methanol (Slightly)
• pka: 13.10±0.40(Predicted)
• form: Solid
• color: White to Off-White
• Merck: 14,8055
• CAS DataBase Reference: 152-43-2(CAS DataBase Reference)

Description and Uses

Quinestrol is a synthetic estrogen that is effective in hormone replacement therapy. It is a 3-cyclopentyl ether of ethynyl estradiol. After gastrointestinal absorption, it is stored in adipose tissue, where it is slowly released and metabolized in the liver to its active form, ethinyl estradiol. Quinestrol has found limited use in suppressing lactation in postpartum women and, in combination with synthetic progestogens, as contraceptive therapy, although additional studies are needed for both applications.

antibacterial, antimycoplasmal, isoleucyl-tRNA synthetase inhibitor

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H302+H312+H332-H350-H360
• Precautionary statements: P201-P280-P301+P312-P302+P352+P312-P304+P340+P312-P308+P313
• Hazard Codes: T
• Risk Statements: 45-61-20/21/22-46
• Safety Statements: 53-22-36/37/39-45
• WGK Germany: 3
• RTECS: RC8948000