Drospirenone , >98.0%(HPLC) , 67392-87-4
Synonym(s):
6β,7β:15β,16β -Dimethylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone;Dihydrospirorenone;Drospirenone
CAS NO.：67392-87-4
Empirical Formula: C24H30O3
Molecular Weight: 366.5
MDL number: MFCD00867350
EINECS: 266-679-2
| Pack Size | Price | Stock | Quantity |
| 50MG | RMB163.20 | In Stock |
|
| 250MG | RMB576.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 196-200°C |
| alpha | -180 º (c=0.5, chloroform) |
| Boiling point: | 552.2±50.0 °C(Predicted) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥15 |
| form | powder |
| color | white to tan |
| optical activity | [α]/D -180 to -195°, c = 1 in methanol |
| InChIKey | METQSPRSQINEEU-URUUTGNFNA-N |
| SMILES | C[C@]12CC[C@]3([H])[C@]4(CCC(=O)C=C4[C@@H]4C[C@@H]4[C@@]3([H])[C@]1([H])[C@@H]1C[C@@H]1[C@]12CCC(=O)O1)C |&1:1,4,6,13,15,16,18,20,22,23,r| |
Description and Uses
Drospirenone is a synthetic progestogen that binds to the progesterone, mineralocorticoid, and androgen receptors with binding affinities of 20, 230, and 65% relative to R5020, aldosterone , and R1881, respectively. In vivo, drospirenone inhibits spontaneous ovulation in rats (ID50s = 0.3-1.0 mg/day) when administered orally or subcutaneously. Drospirenone (0.5 mg/animal) administered six times per day maintains pregnancy in ovariectomized pregnant rats. It reduces serum testosterone (Item Nos. 15645 | ISO60154) and luteinizing hormone in cynomolgus monkeys in a dose-dependent manner. Drospirenone (10 mg/animal per day) also inhibits testosterone-induced growth of the seminal vesicles and prostate in castrated rats. Formulations containing drospirenone have been used as oral contraceptives.
anti-cancer therapeutic
