Dehydroepiandrosterone solution , 1.00mg/ml , 53-43-0
Synonym(s):
DHEA;Dehydroepiandrosterone;Prasterone;Dehydroisoandrosterone;3β-Hydroxy-5-androsten-17-one
CAS NO.：53-43-0
Empirical Formula: C19H28O2
Molecular Weight: 288.43
MDL number: MFCD00003613
EINECS: 200-175-5
| Pack Size | Price | Stock | Quantity |
| 1ML | RMB2399.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 149-151 °C(lit.) |
| alpha | 12 º (c=2, ethanol 96% 25 ºC) |
| Boiling point: | 370.65°C (rough estimate) |
| Density | 1.0484 (rough estimate) |
| refractive index | 1.4709 (estimate) |
| Flash point: | 9℃ |
| storage temp. | Hormones |
| solubility | insoluble in H2O; ≥13.7 mg/mL in DMSO; ≥58.6 mg/mL in ETOH |
| pka | 15.02±0.60(Predicted) |
| form | Fine Crystalline Powder |
| color | White |
| optical activity | +10.918 (c 1, ethanol) |
| Water Solubility | 21.8mg/L(23.5 ºC) |
| Merck | 2871 |
| BRN | 2058110 |
| InChIKey | FMGSKLZLMKYGDP-USOAJAOKSA-N |
| LogP | 3.230 |
| CAS DataBase Reference | 53-43-0 |
| NIST Chemistry Reference | 5-Androstene-3«beta»-ol-17-one(53-43-0) |
| EPA Substance Registry System | Prasterone (53-43-0) |
Description and Uses
Dehydroepiandrosterone(DHEA) is an endogenous steroid hormone that is secreted primarily by the adrenal gland and is the most abundant sex steroid. It is a neurohormone; small quantities of DHEA are produced in the brain and declines in serum and CSF with age. (Knopman and Henderson, 2003). Metabolites of DHEA include androstenedione , which subsequently may be metabolized to testosterone or estrone which is an estradiol precursor. In addition to serving as an intermediate in the biosynthesis of sex steroids, DHEA directly modulates a number of cellular and nuclear receptors.
Dehydroepiandrosterone (DHEA) is a major C19 steroid produced by the adrenal cortex. It is a major secretory steroidal product of the adrenal gland; secretion progresively declines with aging. May have estrogen-or androgen-like effects depending on the hormonal milieu. Intracellularly converted to androstenedione. It is used in treatment of menopausal syndrome. People living with HIV may be interested in taking DHEA for a variety of reasons, including treatment of depression, increasing bone density, decreasing arterial plaques, improvement of immune function with HIV, increased memory, and increased muscle strength.
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Warning |
| Hazard statements | H361fd |
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 |
| Hazard Codes | Xi,T,F |
| Risk Statements | 36/37/38-39/23/24/25-23/24/25-11 |
| Safety Statements | 26-36-24/25-45-36/37-16-7 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 2 |
| RTECS | BV8396000 |
| HS Code | 29372900 |
