trans-Dehydroandrosterone , 99% , 53-43-0

Synonym(s):
DHEA;Dehydroepiandrosterone;Prasterone;Dehydroisoandrosterone;3β-Hydroxy-5-androsten-17-one

CAS NO.：53-43-0

Empirical Formula: C19H28O2

Molecular Weight: 288.43

MDL number: MFCD00003613

EINECS: 200-175-5

PRODUCT Properties

• Melting point: 149-151 °C(lit.)
• alpha: 12 º (c=2, ethanol 96% 25 ºC)
• Boiling point: 370.65°C (rough estimate)
• Density: 1.0484 (rough estimate)
• refractive index: 1.4709 (estimate)
• Flash point: 9℃
• storage temp.: Hormones
• solubility: insoluble in H2O; ≥13.7 mg/mL in DMSO; ≥58.6 mg/mL in ETOH
• pka: 15.02±0.60(Predicted)
• form: Fine Crystalline Powder
• color: White
• optical activity: +10.918 (c 1, ethanol)
• Water Solubility: 21.8mg/L(23.5 ºC)
• Merck: 2871
• BRN: 2058110
• InChIKey: FMGSKLZLMKYGDP-USOAJAOKSA-N
• LogP: 3.230
• CAS DataBase Reference: 53-43-0
• NIST Chemistry Reference: 5-Androstene-3«beta»-ol-17-one(53-43-0)
• EPA Substance Registry System: Prasterone (53-43-0)

Description and Uses

Dehydroepiandrosterone(DHEA) is an endogenous steroid hormone that is secreted primarily by the adrenal gland and is the most abundant sex steroid. It is a neurohormone; small quantities of DHEA are produced in the brain and declines in serum and CSF with age. (Knopman and Henderson, 2003). Metabolites of DHEA include androstenedione , which subsequently may be metabolized to testosterone or estrone which is an estradiol precursor. In addition to serving as an intermediate in the biosynthesis of sex steroids, DHEA directly modulates a number of cellular and nuclear receptors.

Dehydroepiandrosterone (DHEA) is a major C19 steroid produced by the adrenal cortex. It is a major secretory steroidal product of the adrenal gland; secretion progresively declines with aging. May have estrogen-or androgen-like effects depending on the hormonal milieu. Intracellularly converted to androstenedione. It is used in treatment of menopausal syndrome. People living with HIV may be interested in taking DHEA for a variety of reasons, including treatment of depression, increasing bone density, decreasing arterial plaques, improvement of immune function with HIV, increased memory, and increased muscle strength.

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H361fd
• Precautionary statements: P201-P202-P280-P308+P313-P405-P501
• Hazard Codes: Xi,T,F
• Risk Statements: 36/37/38-39/23/24/25-23/24/25-11
• Safety Statements: 26-36-24/25-45-36/37-16-7
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 2
• RTECS: BV8396000
• HS Code: 29372900