Dydrogesterone? , ≥99% , 152-62-5

Synonym(s):
9β,10α-Pregna-4,6-diene-3,20-dione

CAS NO.：152-62-5

Empirical Formula: C21H28O2

Molecular Weight: 312.45

MDL number: MFCD00867864

EINECS: 205-806-8

PRODUCT Properties

• Melting point: 168-173°C
• alpha: D25 -484.5° (chloroform)
• Boiling point: 392.36°C (rough estimate)
• Density: 1.0697 (rough estimate)
• refractive index: 1.4900 (estimate)
• storage temp.: 2-8°C
• solubility: Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent).
• form: Solid
• color: White to Light Yellow
• InChI: InChI=1/C21H28O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4-5,12,16-19H,6-11H2,1-3H3/t16-,17+,18-,19+,20+,21+/s3
• InChIKey: JGMOKGBVKVMRFX-HQZYFCCVSA-N
• SMILES: C[C@@]12CCC(=O)C=C1C=C[C@@]1([H])[C@]3([H])CC[C@H](C(=O)C)[C@@]3(C)CC[C@@]21[H] |&1:1,10,12,16,20,24,r|
• CAS DataBase Reference: 152-62-5(CAS DataBase Reference)

Description and Uses

Dydrogesterone is a synthetic progestogen that has no estrogenic, androgenic, glucocorticoid, or anabolic effects, although it is an agonist of progesterone receptors (EC₅₀ = 12.3 nM) and an antagonist of androgen, mineralocorticoid, and glucocorticoid receptors (IC₅₀s = 28.6, 82.7, and 363 nM, respectively). Dydrogesterone protects against sound stress-induced abortion in mice when administered at a dose of 1.25 mg per animal prior to the stressor on day five of pregnancy. Formulations containing dydrogesterone have been used in hormone replacement therapy, in the treatment of menstrual disorders, and to prevent miscarriage.

central stimulant, convulsant

Safety

• Symbol(GHS): GHS08,GHS09
• Signal word: Danger
• Hazard statements: H372-H410
• Precautionary statements: P260-P264-P270-P314-P501-P273-P391-P501
• RIDADR: UN 3077 9 / PGIII
• Hazardous Substances Data: 152-62-5(Hazardous Substances Data)
• Toxicity: LD50 oral in rat: > 4600mg/kg