Doxycycline hyclate , ≥98% , 24390-14-5

Synonym(s):
α-6-Deoxy-5-hydroxytetracycline, Vibramycin, Hyclate;Doxycycline hyclate;Doxycycline hydrochloride hemiethanolate hemihydrate;Doxycycline, Hyclate - CAS 24390-14-5 - Calbiochem

CAS NO.：24390-14-5

Empirical Formula: C24H31ClN2O9

Molecular Weight: 526.97

MDL number: MFCD06200253

EINECS: 2017-001-1

PRODUCT Properties

• Melting point: 206-209?C (dec.)
• alpha: D25 -110° (c = 1 in 0.01N methanolic HCl)
• RTECS: QI8925000
• storage temp.: 2-8°C
• solubility: H2O: soluble50mg/mL
• form: Yellow to yellow-green crystalline solid
• color: yellow to greenish-yellow
• Water Solubility: Soluble in water to 50mg/ml. May require warming.Soluble in water, methanol. Sparingly soluble in ethanol. Insoluble in chloroform and ether.
• Merck: 14,3440
• BRN: 5702728
• InChIKey: HALQELOKLVRWRI-VDBOFHIQSA-N
• SMILES: C(O)C.O[C@@]12C(C(C(=O)N)=C(O)[C@@H](N(C)C)[C@]1([H])[C@H]([C@]1([H])[C@H](C3C=CC=C(O)C=3C(=O)C1=C2O)C)O)=O.Cl |&1:4,12,16,18,19,21,r|

Description and Uses

Doxycycline Hyclate is the hyclate salt form of doxycycline, is a broad-spectrum tetracycline antibiotic. It inhibits bacterial protein synthesis by binding to ribosomes. Doxycycline also selectively inhibits human matrix metalloproteinase-8 (MMP-8) and MMP-13 over MMP-1 with 50, 60, and 5% inhibition, respectively, when used at a concentration of 30 μM. It can be used as a regulator for inducible gene expression systems where expression depends on either the presence (Tet-On) or absence (Tet-Off) of doxycycline. Formulations containing doxycycline have been used in the treatment of bacterial infections and the prevention of malaria.

Doxycycline hyclate is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is used in the treatment of chlamydia, rickettsia, mycoplasma and some spirochete infections. It is also used to inhibit matrix metalloproteinases at subantimicrobial doses. Inhibits matrix metalloproteinases at subantimicrobial doses.

Safety

• Symbol(GHS): GHS07,GHS08,GHS09
• Signal word: Warning
• Hazard statements: H315-H319-H335-H361fd-H410
• Precautionary statements: P202-P261-P273-P302+P352-P305+P351+P338-P308+P313
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HS Code: 29413000
• Toxicity: LD50 i.p. in rats: 262 mg/kg (Goldenthal)