Doxycyclinemonohydrate , ≥98% , 17086-28-1

CAS NO.：17086-28-1

Empirical Formula: C22H26N2O9

Molecular Weight: 462.45

MDL number: MFCD02682958

EINECS: 605-591-4

PRODUCT Properties

• Melting point: 167-168℃
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: DMSO: soluble1mg/mL
• form: powder or crystals
• color: Light Yellow
• Water Solubility: Soluble in ethanol or methanol. Sparingly soluble in water.Soluble in dilute acids, alkali hydroxides and dimethyl sulfoxide.
• CAS DataBase Reference: 17086-28-1

Description and Uses

Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline. It is a semi-synthetic tetracycline. Doxycycline penetrates the bacterial cell and interferes with the protein biosynthesis, stopping the process. Other microorganisms are also sensitive to the antibiotic activity of Doxycycline, such as Mycoplasma, Chlamydia and Ricketsiae. Resistance to antibiotics of the tetracycline family is primarily due to inhibition of transport of the drug into the cell or by increasing antibiotic efflux. The biological mechanism is mainly through plasmid mediation but it may also occur by chromossomal alteration.

An antimicrobial. Inhibits angiogenesis and reduces lung metastases by inhibiting matrix metalloproteinasesDoxycycline monohydrate acts as an antibiotic, antimicrobial agent and a matrix metalloproteinase inhibitor. It is also used for the treatment of chloroquine-resistant falciparum malaria. Further, it is used to treat a wide variety of bacterial infections, including those that cause acne. In addition to this, it inhibits the bacterial protein synthesis by preventing the interaction of aminoacyl-tRNA and the bacterial ribosome.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312+P330-P501
• Hazard Codes: Xi,Xn
• Risk Statements: 36/37/38-22-63
• Safety Statements: 26-36/37
• WGK Germany: 3
• HS Code: 29413000