PRODUCT Properties
| Melting point: | 205 °C (decomp) |
| Boiling point: | 553.06°C (rough estimate) |
| Density | 1.4033 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | Refrigerator |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Solid |
| pka | pKa 3.5 (Uncertain);7.6 (Uncertain);9.5(EtOH/H2O
t=20.0) (Uncertain) |
| color | Yellow to Brown |
| Water Solubility | 7.548g/L(21 ºC) |
Description and Uses
Methacycline was synthesized by Pfizer Research Laboratories in 1961 starting with oxytetracycline. It shows two to fivefold greater in vitro antibacterial activity and in vivo protective activity than tetracycline. Methacycline has been given orally to treat infections by Rickettsia, Chlamydiae, Staphyloccus, Streptococcus, Neisseria, Klebsiella, Proteus, Escherichia coli, and Haemophilus influenzae.
Methacycline is a tetracycline with broad range antibacterial and antiprotozoal properties. Potential veterinary drug.
