Home Categories API cis-Diammineplatinum dichloride
A3194212

cis-Diammineplatinum dichloride , Pt,65% , 15663-27-1

Synonym(s):
Cisplatin;cis-Platinum (65% Pt);CPDC, DDP, cis-Diaminedichloroplatinum;cis-Diammineplatinum(II) dichloride;cis-Dichlorodiammine platinum(II)

CAS NO.:15663-27-1

Empirical Formula: Cl2H6N2Pt

Molecular Weight: 300.05

MDL number: MFCD00011623

EINECS: 239-733-8

Pack Size Price Stock Quantity
250MG RMB204.00 In Stock
1G RMB584.80 In Stock
5G RMB2335.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 270 °C (lit.)
Density  3,7 g/cm3
storage temp.  2-8°C
solubility  Soluble in DMF. Insoluble in most common solvents
form  crystalline
color  yellow
Water Solubility  <0.1 g/100 mL at 19 ºC
Merck  14,2317
Exposure limits ACGIH: TWA 0.002 mg/m3
NIOSH: IDLH 4 mg/m3; TWA 0.002 mg/m3
Stability: Stable. Incompatible with oxidizing agents, aluminium, antioxidants.

Description and Uses

Cisplastin is an non-organic platinum-containing drug with alkylating properties. It causes cross-linking of DNA and RNA chains. In particular, it has been shown, that cisplastin, like other alkylating agents, bind primarily at N7 of two neighboring deoxyguanylates to DNA, which inhibits its replication. It is only used intravenously. It is highly reactive with carcinomas of the testicles, ovaries, heat, neck, spleen, lungs, and so on.

Cisplatin is a cytostatic agent and it is used to treat various cancer types, including cancer of ovary, testis, lung, head, neck, bladder, neuroblastoma, and nephroblastoma, and Hodgkin’s disease and non-Hodgkin lymphoma.

Safety

Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H300-H315-H317-H319-H334-H335-H350
Precautionary statements  P201-P280-P301+P310-P302+P352-P304+P340+P312-P305+P351+P338
Hazard Codes  T
Risk Statements  45-25-41-60-46-42/43-36/37/38
Safety Statements  53-26-39-45-99-36/37/39-22
RIDADR  UN 3288 6.1/PG 2
WGK Germany  3
RTECS  TP2455000
10-21
TSCA  Yes
HS Code  2843 90 90
HazardClass  6.1(a)
PackingGroup  II
Toxicity LD50 in guinea pigs: 9.7 mg/kg i.p. (Fleishman)

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