cis-Diammineplatinum dichloride , Pt,65% , 15663-27-1

Synonym(s):
Cisplatin;cis-Platinum (65% Pt);CPDC, DDP, cis-Diaminedichloroplatinum;cis-Diammineplatinum(II) dichloride;cis-Dichlorodiammine platinum(II)

CAS NO.：15663-27-1

Empirical Formula: Cl2H6N2Pt

Molecular Weight: 300.05

MDL number: MFCD00011623

EINECS: 239-733-8

PRODUCT Properties

• Melting point: 270 °C (lit.)
• Density: 3,7 g/cm³
• storage temp.: 2-8°C
• solubility: Soluble in DMF. Insoluble in most common solvents
• form: crystalline
• color: yellow
• Water Solubility: <0.1 g/100 mL at 19 ºC
• Merck: 14,2317
• Exposure limits: ACGIH: TWA 0.002 mg/m3; NIOSH: IDLH 4 mg/m3; TWA 0.002 mg/m3
• Stability: Stable. Incompatible with oxidizing agents, aluminium, antioxidants.

Description and Uses

Cisplastin is an non-organic platinum-containing drug with alkylating properties. It causes cross-linking of DNA and RNA chains. In particular, it has been shown, that cisplastin, like other alkylating agents, bind primarily at N7 of two neighboring deoxyguanylates to DNA, which inhibits its replication. It is only used intravenously. It is highly reactive with carcinomas of the testicles, ovaries, heat, neck, spleen, lungs, and so on.

Cisplatin is a cytostatic agent and it is used to treat various cancer types, including cancer of ovary, testis, lung, head, neck, bladder, neuroblastoma, and nephroblastoma, and Hodgkin’s disease and non-Hodgkin lymphoma.

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H300-H315-H317-H319-H334-H335-H350
• Precautionary statements: P201-P280-P301+P310-P302+P352-P304+P340+P312-P305+P351+P338
• Hazard Codes: T
• Risk Statements: 45-25-41-60-46-42/43-36/37/38
• Safety Statements: 53-26-39-45-99-36/37/39-22
• RIDADR: UN 3288 6.1/PG 2
• WGK Germany: 3
• RTECS: TP2455000
• F: 10-21
• TSCA: Yes
• HS Code: 2843 90 90
• HazardClass: 6.1(a)
• PackingGroup: II
• Toxicity: LD50 in guinea pigs: 9.7 mg/kg i.p. (Fleishman)