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A7692558

Oxaliplatin , 2mMinWater , 61825-94-3

Synonym(s):
[SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N′)[ethanedioata(2--)-O,O’]platinum;Oxaliplatin

CAS NO.:61825-94-3

Empirical Formula: C8H12N2O4Pt

Molecular Weight: 395.28

MDL number: MFCD00866327

EINECS: 621-248-1

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

alpha  +74.5-78.0 (D/20)(c=0.5,H2O)
storage temp.  2-8°C
solubility  Slightly soluble in water, very slightly soluble in methanol, practically insoluble in anhydrous ethanol.
form  solid
color  White to Almost white
Water Solubility  Soluble in water with heating and/or sonication
Merck  14,6912
Stability: Stable. Store cool. Incompatible with oxidizing agents.
InChI InChI=1/C6H12N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-8H,1-4H2;(H,3,4)(H,5,6);/q-2;;+4/p-2/t5-,6-;;/s3
InChIKey ZROHGHOFXNOHSO-BNTLRKBRSA-L
SMILES O=C1C([O-][Pt+2]2(N[C@]3([H])CCCC[C@@]3([H])N2)[O-]1)=O |&1:6,12,r|

Description and Uses

Oxaliplatin is a second generation platinum drug prepared in three steps from either k2tCl4 or K2Ptl4. It has an antitumor spectrum similar to cisplatin, however, it is more effective against L1210 leukemia and cisplatin resistant L1210. It is also effective against B16 melanoma but has a dose limiting toxicity of peripheral sensory neuropathy that is reversible upon cessation of the drug. The (R,R)- enantiomer has greater activity than the (S,S)-isomer but this is tumor line dependent, e.g., there was no difference found for P-388 or Sarcoma 180. Clinical drug administration based on circadium timing showed it was better tolerated when given 16 h after the onset of light. Oxaliplatin binds to guanineN7 and can lead to bidentate chelation that results in the bending of DNA. This feature is recognized by high mobility group proteins (HMG) which impedes repair reactions and stops replication and transcription.

A potent anti-neoplastic agent that binds to DNA and shows efficacy in Cisplatin resistant cell lines

Safety

Symbol(GHS) 
GHS07,GHS08
Signal word  Danger
Hazard statements  H315-H317-H319-H335-H340-H360D
Precautionary statements  P202-P261-P280-P302+P352-P305+P351+P338-P308+P313
Hazard Codes  Xn,Xi
Risk Statements  36/37/38-40-42/43
Safety Statements  26-36
RIDADR  2811
WGK Germany  3
RTECS  TP2275850
HazardClass  6.1(a)
PackingGroup  II
HS Code  28439000
Toxicity LD50 intraperitoneal in mouse: 19800ug/kg

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