Oxaliplatin , 99% , 61825-94-3

Synonym(s):
[SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N′)[ethanedioata(2--)-O,O’]platinum;Oxaliplatin

CAS NO.：61825-94-3

Empirical Formula: C8H12N2O4Pt

Molecular Weight: 395.28

MDL number: MFCD00866327

EINECS: 621-248-1

PRODUCT Properties

• alpha: +74.5-78.0 (D/20)(c=0.5,H2O)
• storage temp.: 2-8°C
• solubility: Slightly soluble in water, very slightly soluble in methanol, practically insoluble in anhydrous ethanol.
• form: solid
• color: White to Almost white
• Water Solubility: Soluble in water with heating and/or sonication
• Merck: 14,6912
• Stability: Stable. Store cool. Incompatible with oxidizing agents.
• InChI: InChI=1/C6H12N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-8H,1-4H2;(H,3,4)(H,5,6);/q-2;;+4/p-2/t5-,6-;;/s3
• InChIKey: ZROHGHOFXNOHSO-BNTLRKBRSA-L
• SMILES: O=C1C([O-][Pt+2]2(N[C@]3([H])CCCC[C@@]3([H])N2)[O-]1)=O |&1:6,12,r|
• CAS DataBase Reference: 61825-94-3

Description and Uses

Oxaliplatin is a second generation platinum drug prepared in three steps from either k2tCl4 or K2Ptl4. It has an antitumor spectrum similar to cisplatin, however, it is more effective against L1210 leukemia and cisplatin resistant L1210. It is also effective against B16 melanoma but has a dose limiting toxicity of peripheral sensory neuropathy that is reversible upon cessation of the drug. The (R,R)- enantiomer has greater activity than the (S,S)-isomer but this is tumor line dependent, e.g., there was no difference found for P-388 or Sarcoma 180. Clinical drug administration based on circadium timing showed it was better tolerated when given 16 h after the onset of light. Oxaliplatin binds to guanineN7 and can lead to bidentate chelation that results in the bending of DNA. This feature is recognized by high mobility group proteins (HMG) which impedes repair reactions and stops replication and transcription.

A potent anti-neoplastic agent that binds to DNA and shows efficacy in Cisplatin resistant cell lines

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H315-H317-H319-H335-H340-H360D
• Precautionary statements: P202-P261-P280-P302+P352-P305+P351+P338-P308+P313
• Hazard Codes: Xn,Xi
• Risk Statements: 36/37/38-40-42/43
• Safety Statements: 26-36
• RIDADR: 2811
• WGK Germany: 3
• RTECS: TP2275850
• HazardClass: 6.1(a)
• PackingGroup: II
• HS Code: 28439000
• Toxicity: LD50 intraperitoneal in mouse: 19800ug/kg