Betamethasone 17-valerate , ≥98.0% , 2152-44-5
Synonym(s):
1,4-Pregnadiene-11β,17α,21-triol-9α-fluoro-16β-methyl-3,20-dione 17-valerate;9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-valerate;9α-Fluoro-16β-methylprednisolone 17-valerate;Betamethasone 17-valerate;Betnovate
CAS NO.：2152-44-5
Empirical Formula: C27H37FO6
Molecular Weight: 476.58
MDL number: MFCD00867446
EINECS: 218-439-3
| Pack Size | Price | Stock | Quantity |
| 1G | RMB144.80 | In Stock |
|
| 5G | RMB296.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 183-184° |
| alpha | D +77° (dioxane) |
| Boiling point: | 598.9±50.0 °C(Predicted) |
| Density | 1.1174 (estimate) |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, freely soluble in acetone and in methylene chloride, soluble in ethanol (96 per cent). |
| form | Solid |
| pka | 12.90±0.70(Predicted) |
| color | White |
| Merck | 13,1183 |
| BRN | 4240001 |
| InChIKey | SNHRLVCMMWUAJD-SUYDQAKGSA-N |
| SMILES | [C@]12(C)C[C@@H]([C@]3(F)[C@@]4(C)C=CC(=O)C=C4CC[C@@]3([H])[C@]1([H])C[C@H](C)[C@@]2(C(=O)CO)OC(=O)CCCC)O |&1:0,3,4,6,16,18,21,23,r| |
| CAS DataBase Reference | 2152-44-5(CAS DataBase Reference) |
| EPA Substance Registry System | .beta.-Methasone 17-valerate (2152-44-5) |
Description and Uses
Betamethasone 17-valerate is a synthetic glucocorticoid ester. It is the 17-valerate ester of betamethasone. Betamethasone 17-valerate is often used to treat mild eczema with good efficacy and lower incidence of steroid induced adverse effects due to its lower potency compared to other glucocorticoids. It is available in cream, ointment, lotion, and foam preparations for topical use.
Betamethasone 17-Valerate is a glucocorticoid with anti-inflammatory properties and immunosuppressive activity. It is an antiepileptic non-selective phosphodiesterase inhibitor. Topical application of Betamethasone 17-Valerate has been shown to inhibit heat-induced vasodilatation in man. As a medium-strength corticosteroid, this medication is used to treat a variety of skin conditions (such as eczema, dermatitis, allergies, rash). Betamethasone reduces the swelling, itching, and redness that can occur in these types of conditions.
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Danger |
| Hazard statements | H360D-H373 |
| Precautionary statements | P201-P202-P260-P280-P308+P313-P405 |
| Hazard Codes | Xn |
| Risk Statements | 48 |
| Safety Statements | 22-24/25 |
| RTECS | TU3835000 |
| HS Code | 2937229000 |
| Toxicity | mouse,LD50,intraperitoneal,632mg/kg (632mg/kg),Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973. |
