Betamethasonesolutionstandardsubstanceinmethanol , 100mg/L in methanol

Synonym(s):
9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione;9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione;9α-Fluoro-16β-methylprednisolone;Betamethasone;Betamethasone valerate impurity A (PhEur)

CAS NO.：

Empirical Formula: C22H29FO5

Molecular Weight: 392.47

MDL number: MFCD00062969

EINECS: 206-825-4

PRODUCT Properties

• Melting point: 235-237°C
• alpha: D +108° (acetone)
• Boiling point: 568.2±50.0 °C(Predicted)
• Density: 1.1283 (estimate)
• refractive index: 118 ° (C=1, Dioxane)
• storage temp.: 0-6°C
• solubility: Practically insoluble in water, sparingly soluble in anhydrous ethanol, very slightly soluble in methylene chloride.
• pka: 12.13±0.70(Predicted)
• form: Solid
• color: White to Off-White
• Water Solubility: 58mg/L(25 ºC)
• Merck: 14,1180
• LogP: 2.01 at 25℃

Description and Uses

Betamethasone is a synthetic corticosteroid. Like other corticosteroids, betamethasone has anti-inflammatory actions. Betamethasone also accelerates fetal lung maturation and has been used to decrease neonatal mortality and morbidity in infants born before 34 weeks of gestation.

anti-inflammatory, immunosuppressive

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H360FD-H373
• Precautionary statements: P202-P260-P280-P308+P313-P405-P501
• Hazard Codes: Xi,Xn,T
• Risk Statements: 40-48/20/21-61
• Safety Statements: 22-36-45-53
• WGK Germany: 2
• RTECS: TU4000000
• HS Code: 29379000
• Toxicity: LD50 oral in mouse: > 4500mg/kg