Ropinirolehydrochloride , ≥99% , 91374-20-8
Synonym(s):
4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride;Ropinirole hydrochloride;SKF 101468 hydrochloride
CAS NO.:91374-20-8
Empirical Formula: C16H25ClN2O
Molecular Weight: 296.84
MDL number: MFCD01754173
EINECS: 635-615-9
Pack Size | Price | Stock | Quantity |
10mg | RMB71.20 | In Stock |
|
50mg | RMB215.20 | In Stock |
|
100mg | RMB260.80 | In Stock |
|
250mg | RMB388.80 | In Stock |
|
1g | RMB976.00 | In Stock |
|
others | Enquire |
PRODUCT Properties
Melting point: | 241-243°C |
storage temp. | 2-8°C |
solubility | H2O: >10mg/mL |
form | powder |
color | light yellow |
InChI | InChI=1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H |
InChIKey | XDXHAEQXIBQUEZ-UHFFFAOYSA-N |
SMILES | C12CC(=O)NC=1C=CC=C2CCN(CCC)CCC.Cl |
CAS DataBase Reference | 91374-20-8(CAS DataBase Reference) |
Description and Uses
ReQuip was launched in the UK as a monotherapy or in combination with low-dose levodopa for the treatment of early-stage idiopathic Parkinson's disease. An eight step (24% overall yield) synthesis from isochroman provides access to ropinirole. It is a non-ergot postsynaptic dopamine D2 agonist with activity in the extrapyramidal system. It has weak or no significant activity at α2-adrenergic, 5-HT2 receptors and is inactive at 5-HT1, benzodiazepine, GABA, α1 and β adrenoreceptors. Thus it has essentially no CNS side effects, fewer dyskinesias and on-off fluctuations. In animals, it was able to reverse all motor deficits induced by MPTP. Tolerance is not developed and ropinirole has similar postsynaptic potency to apomorphine but with significantly less stereotyped behavior.
antiparkinsonian;non-ergoline D2, D3, and D4 dopamine receptor agonist with highest affinity for D3
Safety
Symbol(GHS) | GHS07,GHS09 |
Signal word | Warning |
Hazard statements | H302-H400 |
Precautionary statements | P273-P301+P312+P330 |
Hazard Codes | Xn,N,Xi |
Risk Statements | 22-50/53-36/38 |
Safety Statements | 36-60-61-37/39-26 |
RIDADR | UN 3077 9/PG 3 |
WGK Germany | 3 |
RTECS | NM3288250 |
HS Code | 2933790002 |