Riluzole , ≥98% , 1744-22-5

Synonym(s):
2-Amino-6-(trifluoromethoxy)benzothiazole;2-Amino-6-(trifluoromethoxy)benzothiazole, PK 26124;Riluzole - CAS 1744-22-5 - Calbiochem

CAS NO.：1744-22-5

Empirical Formula: C8H5F3N2OS

Molecular Weight: 234.2

MDL number: MFCD00210213

EINECS: 605-724-6

PRODUCT Properties

• Melting point: 116-118°C
• Boiling point: 296.3±50.0 °C(Predicted)
• Density: 1.572±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: ≥25 mg/mL
• form: solid
• pka: 2.96±0.10(Predicted)
• color: white
• Merck: 14,8223
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
• InChIKey: FTALBRSUTCGOEG-UHFFFAOYSA-N

Description and Uses

Rilutek was launched in Germany, the UK and US (orphan drug status) for treatment of amyotrophic lateral sclerosis (ALS) and is the first drug approved for this indication. A one step synthesis from 4-(trifluoromethoxy)aniline provides a supply of the compound. The source of its neuroprotective and anticonvulsant activity is not clearly understood. It antagonizes excitatory amino acids and blocks presynaptic release of glutamate, is an antagonist of NMDA-induced acetylcholine release and inhibited glutamate and quisqualate induced increases in cGMP but does not bind to NMDA or Kainic receptors. Rilutek has no affinity for glutamate, GABAbenzodiazepine, glycine and adenosine receptors. It easily crosses the blood brain barrier and depresses glutamatergic neurotransmission, stabilizes voltagedependent Na channels in their inactive form and activates G-protein dependent processes.

anticonvulsant, glutamate release inhibitor, anti-ALS

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H300
• Precautionary statements: P301+P310+P330
• Hazard Codes: T,Xi
• Risk Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: DL2830000
• Hazard Note: Irritant
• HazardClass: 6.1
• PackingGroup: II
• HS Code: 29342000
• Toxicity: LD50 in mice (mg/kg): 46 i.p.; 67 orally (Mizoule)