Apixaban , ≥99% , 503612-47-3

CAS NO.：503612-47-3

Empirical Formula: C25H25N5O4

Molecular Weight: 459.5

MDL number: MFCD11977295

EINECS: 639-684-6

PRODUCT Properties

• Melting point: 235-238°C
• Boiling point: 770.5±60.0 °C(Predicted)
• Density: 1.42
• storage temp.: Refrigerator
• solubility: DMSO (Slightly, Heated), Methanol (Slightly)
• pka: 15.01±0.20(Predicted)
• form: Solid
• color: White to Off-White
• InChIKey: QNZCBYKSOIHPEH-UHFFFAOYSA-N
• SMILES: C1(=O)N(C2=CC=C(N3CCCCC3=O)C=C2)CCC2C(C(N)=O)=NN(C3=CC=C(OC)C=C3)C1=2

Description and Uses

Eliquis (apixaban), a direct inhibitor of factor Xa (FXa), was approved by the European Commission on May 18, 2011 for prevention of venous thromboembolic events (VTE) in adult patients who have undergone elective hip or knee replacement surgery. Apixaban (357.5 mg) also prevents thrombus formation without inducing adverse bleeding events in a porcine model of aortic heterotopic valve replacement. Formulations containing apixaban have been used to prevent blood clot formation in patients with atrial fibrillation.

Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively.

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H361
• Precautionary statements: P501-P202-P201-P280-P308+P313-P405
• Hazardous Substances Data: 503612-47-3(Hazardous Substances Data)