(+)-JQ1 , 98%(HPLC) , 1268524-70-4

Synonym(s):
(S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6S)-

CAS NO.：1268524-70-4

Empirical Formula: C23H25ClN4O2S

Molecular Weight: 456.99

MDL number: MFCD22683748

PRODUCT Properties

• Melting point: >205°C (dec.)
• Boiling point: 610.4±65.0 °C(Predicted)
• Density: 1.33
• storage temp.: 2-8°C
• solubility: DMSO: soluble20mg/mL, clear
• form: powder
• pka: 2.05±0.60(Predicted)
• color: white to beige
• Stability: Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
• InChIKey: DNVXATUJJDPFDM-KRWDZBQOSA-N

Description and Uses

JQ1 (+) (1268524-70-4) is a potent BET bromodomain inhibitor and is the active isomer.?? IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively (data for + isomer).1 Competitive binding by JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models.1?Induces squamous differentiation in NMC cell lines and inhibits tumor growth in NMC xenografts.2?Displays reversible contraceptive effects in male mice.3?Blocks inflammation and bone loss in periodontitis.4?Reverses CAR T cell extinction.5

(+)-JQ1 has been used in flow cytometry assay, cell viability assay and quantitative PCR assay in order to investigate on the reversal of HIV-1 latency.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H332-H335
• Precautionary statements: P261-P280-P305+P351+P338