Antipyrine , 99% , 60-80-0

Synonym(s):
2,3-Dimethyl-1-phenyl-3-pyrazolin-5-one;Antipyrine;Marenostrin;Phenazone;Phenazonum

CAS NO.：60-80-0

Empirical Formula: C11H12N2O

Molecular Weight: 188.23

MDL number: MFCD00003146

EINECS: 200-486-6

PRODUCT Properties

• Melting point: 109-111 °C(lit.)
• Boiling point: 319 °C
• Density: 1,19 g/cm³
• refractive index: 1.5850 (estimate)
• storage temp.: 2-8°C
• solubility: H2O: soluble1 gm in less than 1ml
• form: Crystalline Powder
• pka: pKa 1.4 (Uncertain)
• color: White
• Water Solubility: 1000 g/L (20 ºC)
• Merck: 14,716
• BRN: 157775
• Stability: Stable. Incompatible with ammonia, strong acids, alkalies, strong oxidizing agents, metallic salts, phenol.
• LogP: 0.380
• CAS DataBase Reference: 60-80-0(CAS DataBase Reference)
• NIST Chemistry Reference: Antipyrine(60-80-0)
• EPA Substance Registry System: Antipyrine (60-80-0)

Description and Uses

Antipyrine has been used for immunoblotting. It has also been used as an internal reference marker for studying the transport characteristics of platinum-containing drug, cisplatin in the human placenta in vitro. Antipyrine is an analgesic and antipyretic that has been given by mouth and as ear drops. It is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P501
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38
• Safety Statements: 26-36-37/39
• RIDADR: 3249
• WGK Germany: 1
• RTECS: CD2450000
• F: 10
• TSCA: Yes
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29331190
• Toxicity: LD50 orally in rats: 1.8 g/kg (Hart)