Sildenafil Citrate , ≥98%(HPLC) , 171599-83-0

Synonym(s):
1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate salt;5-[2-Ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[5,4-e]pyrimidin-7-one citrate salt;Revatio;Sildenafil citrate salt;UK-92,480

CAS NO.：171599-83-0

Empirical Formula: C28H38N6O11S

Molecular Weight: 666.7

MDL number: MFCD02102122

EINECS: 200-659-6

PRODUCT Properties

• Melting point: 187-189°C
• storage temp.: 2-8°C
• solubility: DMSO: >20mg/mL
• form: white powder
• color: White
• Water Solubility: 3.488g/L(temperature not stated)
• Merck: 14,8489
• BCS Class: 1
• Stability: Store in Freezer
• InChIKey: DEIYFTQMQPDXOT-UHFFFAOYSA-N
• SMILES: C1(=CC(=CC=C1OCC)S(=O)(=O)N1CCN(C)CC1)C1=NC(C2N(N=C(CCC)C=2N1)C)=O.C(O)(C(=O)O)(CC(=O)O)CC(=O)O

Description and Uses

Sildenafil is a potent inhibitor of phosphodiesterase 5 (PDE5) with IC₅₀ values of 3.6 and 3 nM for PDE5 activity in isolated rabbit platelets and human corpus cavernosum, respectively. It is selective for PDE5 over PDE1 and PDE3 (IC₅₀s = 0.26 and 65 μM, respectively). Sildenafil reverses glucose-induced decreases in angiopoietin 1 (ANG1) expression and reduction of capillary-like tube formation by mouse dermal endothelial cells in vitro and increases the number of functional blood vessels and regional blood flow in the sciatic nerve in a db/db mouse model of diabetic peripheral neuropathy. It increases the ratio of maximum intracavernosal pressure to mean arterial blood pressure (ICP/MAP), a measure of erectile function, in castrated rats when administered at a dose of 20 mg/kg per day. Sildenafil (0.5 mg/kg) also reduces cardiac arrest and resuscitation-induced increases in angiotensin II , angiotensin converting enzyme (ACE), ACE2, and various angiotensin receptors and increases survival in a porcine model of ischemia/reperfusion injury. Formulations containing sildenafil have been used in the treatment of erectile dysfunction, pulmonary arterial hypertension, and high-altitude pulmonary edema associated with altitude sickness.

Sildenafil citrate is an orally active selective type 5 cgmp phosphodiesterase inhibitor that is used in the treatment of erectile dysfunction and primary pulmonary hypertension.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 36
• WGK Germany: 3
• RTECS: TL4284390
• HS Code: 2933595960