Dimethyl fumarate , 99% , 624-49-7
Synonym(s):
Dimethyl fumarate;Fumaric acid dimethyl ester
CAS NO.：624-49-7
Empirical Formula: C6H8O4
Molecular Weight: 144.13
MDL number: MFCD00064438
EINECS: 210-849-0
| Pack Size | Price | Stock | Quantity |
| 25G | RMB47.20 | In Stock |
|
| 100G | RMB67.20 | In Stock |
|
| 250g | RMB79.20 | In Stock |
|
| 500G | RMB120.00 | In Stock |
|
| 2.5kg | RMB559.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 102-106 °C (lit.) |
| Boiling point: | 192-193 °C (lit.) |
| Density | 1,37 g/cm3 |
| vapor pressure | 5 hPa (25 °C) |
| refractive index | 1.4062 (estimate) |
| Flash point: | 192-193°C |
| storage temp. | Store below +30°C. |
| solubility | 1.6g/l |
| form | Liquid |
| color | Clear colorless to faintly yellow |
| PH | 4.0-6.0 (10g/l, H2O, 20℃)suspension |
| Water Solubility | Soluble in water (1.6 mg/ml at 20°C), methanol (30-36 mg/ml), ethanol (10 mg/ml at 25°C), DMSO (29 mg/ml at 25°C), and DMF (~12 mg/ml). |
| Merck | 14,4287 |
| BRN | 774590 |
| Stability: | Stable. Incompatible with acids, bases, oxidizing agents, reducing agents. |
| CAS DataBase Reference | 624-49-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Butenedioic acid (E)-, dimethyl ester(624-49-7) |
| EPA Substance Registry System | 2-Butenedioic acid (2E)-, 1,4-dimethyl ester (624-49-7) |
Description and Uses
In March 2013, the US FDA approved dimethyl fumarate for the treatment of relapsing forms of multiple sclerosis (MS). Dimethyl fumarate is the newest oral therapeutic for MS. While its mechanism is not completely understood, dimethyl fumarate increases anti-inflammatory cytokines (IL-10, IL-4, and IL-6), decreases proinflammatory cytokines (IL-1β, IL-6, and TNF-α), and activates the Nrf2 pathway to protect neuronal cells. Nrf2 is activated by covalent bond-forming electrophiles such as dimethyl fumarate, a Michael acceptor. Dimethyl fumarate has been used for the treatment of psoriasis in Europe since 1994 and has a favorable long-term safety profile. An exploratory study in patients with relapsing remitting MS showed significant reductions in MS lesions after 18 weeks of treatment with 720 mg/day of dimethyl fumarate. Evaluation of dimethyl fumarate in a mouse experimental autoimmune encephalomyelitis model of MS resulted in reduced spinal cord macrophage inflammation. Dimethyl fumarate is obtained in high purity by esterification of fumaric acid with methanol and catalytic sulfuric acid.
Dimethyl fumarate acts as an immunomodulator. It is also used in cycloaddition reactions involving ylides, benzenes and amino acids. It is added to food grains,tobacco,leather and preservation. Clothing
Safety
| Symbol(GHS) |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H312-H315-H317-H335-H411 |
| Precautionary statements | P261-P264-P271-P273-P280-P302+P352+P312 |
| Hazard Codes | Xn |
| Risk Statements | 21-38-41-43-36/37/38-36/38 |
| Safety Statements | 26-36/37/39-36/37 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 1 |
| RTECS | EM6125000 |
| TSCA | Yes |
| HS Code | 29171990 |
| Hazardous Substances Data | 624-49-7(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 2240 mg/kg LD50 dermal Rabbit 1250 mg/kg |
