4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoicacid

Synonym(s):
γ-Maleimidobutyric acid;4-Maleimidobutanoic acid;N-(3-Carboxypropyl)maleimide;N-Maleoyl-4-aminobutyric acid;N-Maleoyl-GABA

CAS NO.：

Empirical Formula: C8H9NO4

Molecular Weight: 183.16

MDL number: MFCD00043139

EINECS: 611-461-8

PRODUCT Properties

• Melting point: 95-98 °C
• Boiling point: 400.1±28.0 °C(Predicted)
• Density: 1.395±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly)
• form: Solid
• pka: 4.59±0.10(Predicted)
• color: White to Pale Yellow
• BRN: 1455876
• CAS DataBase Reference: 57078-98-5(CAS DataBase Reference)

Description and Uses

4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid contains a maleimide group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

1. A short crosslinking reagent
2. Modification reagent for thiol groups in proteins
3. Maleimide Derivatives
4. MTS & Sulfhydryl Active Reagents

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10-21
• HS Code: 29251900