Afatinib , >97.0%(HPLC)(N) , 850140-72-6
CAS NO.：850140-72-6
Empirical Formula: C24H25ClFN5O3
Molecular Weight: 485.94
MDL number: MFCD12407405
| Pack Size | Price | Stock | Quantity |
| 50mg | RMB656.00 | In Stock |
|
| 250mg | RMB1880.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 102 °C |
| Boiling point: | 676.9±55.0 °C(Predicted) |
| Density | 1.380 |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). |
| form | Yellow powder. |
| pka | 11.79±0.43(Predicted) |
| color | Pale yellow |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
Description and Uses
Afatinib (850140-72-6) is a clinically useful kinase inhibitor approved for the treatment of non-small cell lung cancer. It is a potent and highly selective inhibitor of mutant and wild-type EGFR (IC50= 0.5 nM) and HER2 (IC50?= 14 nM).
Afatinib is a tyrosine kinase receptor inhibitor that is used to treat metastatic (cancer that has already spread) non-small cell lung cancer (NSCLC) that has certain types of abnormal epidermal growth factor receptor (EGFR) genes in patients who have not received any treatments for cancer that has already spread to other parts of the body. This medicine is also used to treat patients with metastatic squamous NSCLC who have received medicines containing platinum but did not work well.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301+H311+H331 |
| Precautionary statements | P261-P280-P301+P310-P311 |
| HS Code | 29420000 |
