≥95%,synthetic , 41598-07-6

Synonym(s):
PGD2;PGDS;prostaglandin D2 synthase (brain);(5Z,9α,13E,15S)-9,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic-acid;L-PGDS

CAS NO.：41598-07-6

Empirical Formula: C20H32O5

Molecular Weight: 352.47

MDL number: MFCD00077857

EINECS: 636-995-9

PRODUCT Properties

• Melting point: 68°C
• Boiling point: 406.07°C (rough estimate)
• alpha: +7.5°(D/21℃)(c=1,THF)
• Density: 1.0601 (rough estimate)
• refractive index: 1.6120 (estimate)
• storage temp.: -20°C
• solubility: Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly), THF (Slightly)
• pka: 4.76±0.10(Predicted)
• form: White solid
• color: White to Light Orange
• BRN: 2170623
• Stability: Light Sensitive

Description and Uses

Prostaglandin D₂ (PGD₂) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of PGD₂, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD₂ is also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as β-trace. In the brain, PGD₂ produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD₂ inhibits human ovarian tumor cell proliferation with an IC₅₀ of 6.8 μM.

Prostaglandin D2 is a fatty acid compound present in the human body. Elevated levels of localized Prostaglandin D2 has been linked to hair loss and growth inhibition. It has also been seen to contribute to the activity of allergic asthma.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H302-H360
• Precautionary statements: P201-P301+P312+P330-P308+P313
• Hazard Codes: T
• Risk Statements: 60-22
• Safety Statements: 53-22-26-36
• WGK Germany: 3
• RTECS: UK7930000
• F: 10