ProstaglandinD2-1-glycerylester , ≥98% , 309260-52-4

CAS NO.：309260-52-4

Empirical Formula: C23H38O7

Molecular Weight: 426.54

MDL number: MFCD05863733

PRODUCT Properties

• solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): .1 mg/ml

Description and Uses

2-Arachidonoyl glycerol (2-AG; ) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB₁ receptor.^1,2 Incubation of 2-AG with COX-2 and specific prostaglandin H₂ (PGH₂; ) isomerases in cell cultures and isolated enzyme preparations results in prostaglandin glycerol ester formation.³ The biosynthesis of PGH, PGD, PGE, PGF, and TXA-2-glyceryl ester compounds have all been documented. In RAW 264.7 cells, PGD₂-2-glyceryl ester is the main COX metabolite.³ The 2-glyceryl ester moiety equilibrates rapidly (within minutes) with the more stable 1-glyceryl ester, producing a 10:90 mixture of the 1- and 2-glyceryl esters in typical aqueous media. While the stability and metabolism of these PG products have been investigated, little is known about their intrinsic biological activity.⁴