~100 μg/mLinethanol,≥97% , 71160-24-2

Synonym(s):
[5S,12R]-Dihydroxy-[6Z,8E,10E,14Z]-eicosatetraenoic acid;Leukotriene B₄ - CAS 71160-24-2 - Calbiochem;LTB₄, 5(S),12(R)-Dihydroxy-6- cis-8- trans-10- trans-14- cis-eicosatetraenoic Acid

CAS NO.：71160-24-2

Empirical Formula: C20H32O4

Molecular Weight: 336.47

MDL number: MFCD00135630

EINECS: 200-578-6

PRODUCT Properties

• Boiling point: 536.4±50.0 °C(Predicted)
• Density: 1.040±0.06 g/cm3(Predicted)
• Flash point: 14 °C
• storage temp.: -20°C
• solubility: Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 50μg/ml)
• form: Clear oil
• pka: 4.66±0.10(Predicted)
• color: Colorless to light yellow
• CAS DataBase Reference: 71160-24-2(CAS DataBase Reference)

Description and Uses

Leukotriene B₄ (LTB₄) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar ranges (3.9 x 10⁻¹⁰ M), LTB₄ causes chemotaxis and chemokinesis in human polymorphonuclear leukocytes. At higher concentrations, (1.0 x 10⁻⁷ M), LTB₄ leads to neutrophil aggregation and degranulation as well as superoxide anion production.

LTB₄ MaxSpec^® standard is a quantitative grade standard of LTB₄ that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This LTB₄ MaxSpec^® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

LTB4 (Leukotriene B4) is a potent chemokine with roles in inflammation, immunology, the nervous system, brain and skin.

Safety

• Symbol(GHS): GHS02,GHS07
• Signal word: Danger
• Hazard statements: H225-H319
• Precautionary statements: P210-P233-P240-P241-P242-P305+P351+P338
• Hazard Codes: F
• Risk Statements: 11
• Safety Statements: 7-16
• RIDADR: UN 1170 3/PG 2
• WGK Germany: 1