20-carboxyLeukotrieneB4(20-carboxyLTB4) , 98% , 80434-82-8

Synonym(s):
20-Carboxy-LTB4

CAS NO.：80434-82-8

Empirical Formula: C20H30O6

Molecular Weight: 366.45

MDL number: MFCD00065857

PRODUCT Properties

• Boiling point: 588.3±50.0 °C(Predicted)
• Density: 1.151±0.06 g/cm3(Predicted)
• Flash point: 14℃
• storage temp.: −20°C
• solubility: DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS pH 7.2: 1 mg/ml
• form: Liquid
• pka: 4.66±0.10(Predicted)
• color: Colorless to light yellow

Description and Uses

20-carboxy LTB₄ is a metabolite of LTB₄ in human neutrophils. In human leukocytes, LTB₄ is inactivated by the enzyme LTB₄ 20-hydroxylase. The resulting 20-hydroxy LTB₄ is further oxidized to 20-carboxy LTB₄. LTB₄ metabolism in isolated rat hepatocytes also results in production of 20-carboxy LTB₄ along with other ω-oxidation products. The biological activity of 20-carboxy LTB₄ is only about 2.6% compared to that of LTB₄ in causing PMNL degranulation.

20-COOH-LTB4 is a leukotriene B4 metabolite and substrate for β-oxidation pathways.

Safety

• Symbol(GHS): GHS02,GHS07
• Signal word: Danger
• Hazard statements: H225-H315-H319-H335
• Precautionary statements: P210-P261-P305+P351+P338
• Hazard Codes: F,Xi
• Risk Statements: 11-36/37/38
• Safety Statements: 16-26-36
• RIDADR: UN 1170 3/PG 2
• WGK Germany: 3