methylacetatesolution , 39746-25-3

Synonym(s):
16,16-Dimethyl-PGE2

CAS NO.：39746-25-3

Empirical Formula: C22H36O5

Molecular Weight: 380.52

MDL number: MFCD00151141

PRODUCT Properties

• Flash point: -13℃
• storage temp.: -20°C
• solubility: Soluble in methyl acetate
• form: methyl acetate solution
• color: Colorless to light yellow

Description and Uses

16,16-dimethyl PGE₂ is a competitive inhibitor of 15-hydroxy PGDH, but it is not a substrate for the enzyme. Because of its resistance to metabolism by 15-hydroxy PGDH, it has a prolonged half-life in vivo. 16,16-dimethyl PGE₂ acts as an agonist on most EP receptor subtypes, and has been used experimentally to induce cervical ripening, uterine contraction, and prevent ulceration of the gastric mucosa in rats and dogs. The K_d for activation of isolated EP₂ receptors is about 1 nM. 16,16-dimethyl PGE₂ can be used to preserve the self-renewal properties while preventing the differentiation of hematopoietic stem cells during expansion in culture.

Safety

• Symbol(GHS): GHS02,GHS07
• Signal word: Danger
• Hazard statements: H225-H319-H336
• Precautionary statements: P210-P305+P351+P338
• Hazard Codes: F,Xn,Xi
• Risk Statements: 11-20/21/22-36/37/38-67-66-36
• Safety Statements: 16-26-36
• RIDADR: UN 1231 3/PG 2
• WGK Germany: 3