11-deoxy-16,16-dimethylProstaglandinE2(11-deoxy-16,16-dimethylPGE2) , 98% , 53658-98-3

CAS NO.：53658-98-3

Empirical Formula: C22H36O4

Molecular Weight: 364.52

MDL number: MFCD00135216

PRODUCT Properties

• solubility: DMF: >100 mg/ml (from PGE2); DMSO: >100 mg/ml (from PGE2); Ethanol: >100 mg/ml (from PGE2); PBS pH 7.2: >5 mg/ml (from PGE2)

Description and Uses

11-deoxy-16,16-dimethyl PGE₂ is a stable synthetic analog of PGE₂. It is an agonist for both EP₂ and EP₃ receptors. It is an effective inhibitor of gastric acid secretion and ulcer formation in the rat, with ED₅₀ values of 1 mg/kg and 0.021 mg/kg respectively. It is 900 times more potent than PGF_2α in the contraction of human respiratory tract smooth muscle in vitro.

AY 24609 is an analogue of PGE2 and a selective EP2 and EP3 receptors agonist. It also inhibits gastric acid secretion and ulcer formation in rat.

Safety

• Symbol(GHS): GHS02,GHS07,GHS08
• Signal word: Danger
• Hazard statements: H225-H319-H360-H336
• Precautionary statements: P201-P202-P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P308+P313-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501