36011-19-5

CAS NO.：36011-19-5

Empirical Formula: C28H33NO7

Molecular Weight: 495.56

MDL number: MFCD00005178

EINECS: 252-835-7

PRODUCT Properties

• Melting point: 206 °C
• Boiling point: 587.59°C (rough estimate)
• Density: 1.2415 (rough estimate)
• refractive index: 1.6290 (estimate)
• storage temp.: -20°C
• solubility: DMF: 11 mg/ml; DMF:PBS (pH7.2) (1:30): 0.03 mg/ml; DMSO: 10 mg/ml; Ethanol: 2 mg/ml
• form: White solid.
• pka: 11.22±0.70(Predicted)
• color: White to off-white
• BRN: 1096975
• LogP: 1.920 (est)

Description and Uses

The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin E is an epoxide-containing analog of cytochalasin B which potently and selectively inhibits the growth of endothelial cells (IC₅₀ < 1 nM), impairing angiogenesis and tumor growth. This cytochalasin does not inhibit glucose transport or HIV-1 protease activity.

Cytochalasin E has been used as:

• a toxin to study its effects on avocado plants
• a component of the incubating medium in feline junctional adhesion molecule 1 (fJAM-1) expression assay
• an inhibitor of actin polymerization to study its effects on mitochondria uptake by mice endothelial cells

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H300-H310-H330-H361
• Precautionary statements: P260-P264-P280-P284-P301+P310-P302+P350
• Hazard Codes: T+,T
• Risk Statements: 26/27/28-63
• Safety Statements: 28-36/37-45
• RIDADR: UN 1544 6.1/PG 2
• WGK Germany: 3
• RTECS: HA5360000
• F: 10
• HazardClass: 6.1(a)
• PackingGroup: I
• HS Code: 29349990