Cytochalasin B , 98% , 14930-96-2

Synonym(s):
Cytochalasin B, Helminthosporium dematioideum - CAS 14930-96-2 - Calbiochem;Phomin

CAS NO.：14930-96-2

Empirical Formula: C29H37NO5

Molecular Weight: 479.61

MDL number: MFCD00077704

EINECS: 239-000-2

PRODUCT Properties

• Melting point: 218-223 °C
• Boiling point: 577.96°C (rough estimate)
• Density: 1.1490 (rough estimate)
• refractive index: 1.6290 (estimate)
• Flash point: 85℃
• storage temp.: -20°C
• solubility: ethanol: 20 mg/mL
• form: powder
• pka: 13.60±0.70(Predicted)
• color: white
• Merck: 13,2819
• BRN: 1096207
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
• InChIKey: UXVDBQLLXVKPRS-UZBFCAAUSA-N
• LogP: 3.370
• EPA Substance Registry System: Cytochalasin B (14930-96-2)

Description and Uses

Cytochalasin B (14930-96-2) is a cell permeable fungal toxin which binds to the barbed end of actin, inhibiting its polymerization.1 Inhibits cell division, migration and glucose transport.2 Causes cell cycle arrest at G2/M and induces apoptosis in HCT-116 colorectal carcinoma cells.3? Cytochalasin B-induced membrane vesicles (CIMVs) retain cell surface receptors of the parent cells and retain fusion specificity with target cells.4 CIMVs are a promising new vector system for drug and biomolecule delivery due to their natural origin and participation in intercellular communication.5

A cell-permeable fungal toxin used in actin polymerization studies and cytological

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H300+H310+H330-H361
• Precautionary statements: P201-P202-P260-P280-P302+P352+P310-P304+P340+P310
• Hazard Codes: T+,T
• Risk Statements: 26/27/28-63-23/24/25
• Safety Statements: 28-36/37-45
• RIDADR: UN 1544 6.1/PG 2
• WGK Germany: 3
• RTECS: RO0205000
• F: 10
• HazardClass: 6.1(a)
• PackingGroup: I
• HS Code: 29349990
• Hazardous Substances Data: 14930-96-2(Hazardous Substances Data)
• Toxicity: LD50 intraperitoneal in mouse: 30mg/kg