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S8875714

≥98atom%,≥98%(CP) , 387-79-1

Synonym(s):
3β,17α-Dihydroxy-5-pregnen-20-one;5-Pregnene-3β,17α-diol-20-one

CAS NO.:387-79-1

Empirical Formula: C21H32O3

Molecular Weight: 332.48

MDL number: MFCD00021129

EINECS: 206-862-6

Pack Size Price Stock Quantity
1mg RMB4597.32 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 273℃
Flash point: 9℃
storage temp.  -20°C
solubility  Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated)
form  Solid
Boiling point: 478.4±45.0 °C(Predicted)
Density  1.15±0.1 g/cm3(Predicted)
pka 13.02±0.70(Predicted)
color  White to Off-White

Description and Uses

17α-hydroxy Pregnenolone is a metabolite of pregnenolone and a precursor in the biosynthesis of dehydroepiandrosterone (DHEA; ). It is formed from pregnenolone by cytochrome P450 (CYP) isoform CYP17A1 hydroxylase activity and then converted to dehydroepiandrosterone by CYP17A1-mediated 17,20-lyase activity. Plasma levels of 17α-hydroxy pregnenolone are elevated in patients with type II 3β-hydroxysteroid dehydrogenase deficiency, a form of congenital adrenal hyperplasia.

17α-hydroxypregnenolone has been used as a substrate for the enzyme 3β‐hydroxysteroid dehydrogenase (3β‐HSD) expressed in COS1 cells.

Safety

Symbol(GHS) 
GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H225-H301+H311+H331-H370
Precautionary statements  P210-P260-P280-P301+P310-P311
Hazard Codes  F,T
Risk Statements  11-23/24/25-39/23/24/25
Safety Statements  7-16-36/37-45
RIDADR  UN1230 - class 3 - PG 2 - Methanol
WGK Germany  3
RTECS  TU5548000

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